Newsletters

[LEO Pharma A/S] LEO Pharma A/S announced that China's National Medical Products Administration (NMPA) has approved Enstilar^® (calcipotriene/betamethasone dipropionate) to treat adult patients in China living with plaque psoriasis.

[Nature Cell Biology] Investigators showed that a population of melanocytes with low mutation burden persists in sun-exposed epidermis. These cells were smaller, less dendritic, and exhibit stem-like expression profiles when compared to melanocytes carrying high mutation burdens.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified potassium (K⁺) as a crucial nutrient for efficient growth in the skin niche. They showed that putative high-affinity K⁺ transporter Trk1 is required for Candidozyma auris growth on human skin ex vivo.

[Biofabrication] Researchers developed a customized anti-shrinkage device designed to physically constrain the substitute while remaining compatible with the established fabrication process of plastically compressed dermo-epidermal skin substitutes.

[Cell Death & Disease] The authors found decreased bacterial density and dysbiosis associated with reduced amounts of Staphylococcus in the skin of PPARα-deficient mice compared to littermate controls.

[Scientific Reports] Fibroblast-derived matrix human skin equivalents containing either papillary or reticular fibroblasts were generated and analyzed for epidermal differentiation, expression of lipid processing enzymes, stratum corneum lipid matrix structure, and barrier function.

[Journal of Drug Targeting] Researchers addressed the drawback of Naringenin (NG) bioavailability, permeability, stability and half-life with a novel approach to formulate NG-loaded niosomes as a ligand-specific nanocarrier system.

[Lab on a Chip] Scientists review the regenerative approaches to hair restoration, and emphasises the emerging role of engineered in vitro platforms in modelling human hair growth and enabling translational discovery.

[TCM Biotech] TCM Biotech has received FDA Breakthrough Device Designation for CatCHimera, a liquid biopsy MRD platform for HCC that uses HBV–host genome integration junctions — rather than somatic mutations — as tumor-specific circulating biomarkers for post-curative treatment monitoring.

[Advanced Science] Researchers identified an N-methyltransferase (NNMT)-ANGPTL4-driven metabolic-epigenetic cascade in cancer-associated fibroblasts that induces PD-L1-mediated immune evasion, providing a therapeutic strategy to overcome resistance to immunotherapy in patients with HCC.

[Advanced Healthcare Materials] Scientists elucidated a polymeric nanomedicine integrated with protein-binding fluorophore and bevacizumab, named PNPB, that was activated by fibroblast activation protein (FAP), a biomarker of liver fibrosis.

[Journal of Nanobiotechnology] Investigators identified fibrinogen gamma chain (FGG) as a key fibrosis promoter that acts through simultaneous hepatic stellate cell activation and M2 macrophage polarization.