STAT3 Silencing by an Aptamer-Based Strategy Hampers the Crosstalk between NSCLC Cells and Cancer-Associated Fibroblasts

Scientists applied an aptamer-based conjugate, containing a signal transducer and activator of transcription-3 (STAT3) siRNA linked to an aptamer binding and inhibiting the platelet-derived growth factor receptor β, to obtain STAT3 specific silencing and interfere with CAF pro-tumorigenic functions.