Propensity of Patient-Derived iPSCs for Retinal Differentiation: Implications for Autologous Cell Replacement

IPSCs were generated from 15 patients aged 14-76 years old, differentiated into retinal organoids, and scored based on their retinal differentiation capacity. Despite significant differences in retinal differentiation propensity, RNA-sequencing revealed remarkable similarity between patient-derived iPSC lines prior to differentiation.