Newsletters

[Nature Communications] Data from islets of the first 299 organ donors without diabetes analyzed using this pipeline highlights substantial heterogeneity in islet cell composition associated with hormone secretory traits, sex, reported race and ethnicity, genetically predicted ancestry, and genetic risk for T2D.

[Developmental Cell] Using pluripotent stem cell-derived pancreatic progenitor organoids, researchers established a human PDAC model that faithfully reproduces the genetic, epigenetic, and transcriptomic trajectories of tumor initiation and progression, validated against clinical datasets and tumor histopathology.

[Autophagy] Investigators developed a drug screening platform and performed high-content screening using a kinase inhibitor library.

[Cell Death & Disease] Researchers investigated the expression patterns, biological functions, and molecular mechanisms of Proline-rich γ-carboxylated Gla protein 1 (PRRG1) in pancreatic cancer pathogenesis.

[Experimental Cell Research] Investigators demonstrated that the oncogenic kinase Aurora Kinase A (AURKA) drove radioresistance by orchestrating a signaling cascade that inhibited the tumor suppressor PTEN.

[Heliyon] The authors investigated the interference of the RAS-MEK pathway in PDAC cell lines, with their redox homeostasis and a potential ensuing vulnerability to radiation therapy.

[Nature Reviews Gastroenterology & Hepatology] Scientists examine the emergence of pancreatic cell lineages in the embryo through the lens of cellular plasticity, emphasizing how reciprocal interactions with the microenvironment influence lineage decisions.

[Trends In Endocrinology and Metabolism] Investigators compare the mechanistic features of the current models of islet morphogenesis, linking them to established intrinsic and extrinsic signals.

[Cancer Cell] Researchers discovered that the commensal fungus Candida albicans synergizes with Fusobacterium nucleatum to promote colorectal cancer pathogenesis and contributes to poor patient outcomes.

[Nature Cancer] Using serial in vivo orthotopic passaging, investigators developed an immunocompetent mouse model of metastatic colorectal cancer.

[Experimental & Molecular Medicine] Cannabidiol-a nonpsychotomimetic phytocannabinoid derived from the Cannabis sativa plant-was found to dramatically improve body weight loss of mice and stimulate Lgr5⁺ intestinal stem cells proliferation upon a lethal dose of irradiation.

[Cancer Immunology Research] Scientists investigated the tumor-intrinsic factors contributing to tumor microenvironment formation and evaluated genotype-based combination strategies to enhance the efficacy of immunotherapy in colorectal cancer.