SARS-CoV-2 Spike Protein Induces Lung Endothelial Cell Dysfunction and Thrombo-Inflammation Depending on the C3a/C3a Receptor Signaling

Investigators found that spike protein subunit 1 injection in mice transgenic for human angiotensin-converting enzyme 2 induced early loss of lung endothelial thromboresistance at 3 days, as revealed by thrombomodulin loss and von Willebrand factor increase.