Schwann Cell-Encapsulated Chitosan-Collagen Hydrogel Nerve Conduit Promotes Peripheral Nerve Regeneration in Rodent Sciatic Nerve Defect Models

Scientists prepared a chitosan-collagen hydrogel nerve conduit (CCN) consisting of an outer layer of chitosan hydrogel and an inner layer of collagen hydrogel to encapsulate the intended cells. Rats with a 10-mm sciatic nerve defect were treated with Schwann cells (SCs) encapsulated in CCN, CCN without SCs , SC-encapsulated silicone tube, and autologous nerve transplanting