FACT Regulates Pluripotency through Proximal and Distal Regulation of Gene Expression in Murine Embryonic Stem Cells

To explore the mechanism for FAcilitates Chromatin Transactions (FACT) function, investigators generated auxin-inducible degron-tagged murine embryonic cell lines for FACT subunit suppressor of Ty 16 homolog and paired depletion with nascent transcription and chromatin accessibility analyses.