Newsletters

[Cell Death & Differentiation] Investigators reported that sublethal oxidative stress activates a β cell-enriched epigenetic switch that licenses intrinsic inflammation.

[Diabetes] Scientists combined human islet single-cell transcriptomics with mouse pancreatic-cell profiling to show that pericytes, rather than endothelial cells, are the primary source of hepatocyte growth factor (HGF) in healthy islets.

[Journal of Materials Chemistry B] The authors reported the development of a sulfonium lipid nanoparticle system for pancreas-specific interleukin-10 mRNA delivery in acute pancreatitis.

[Cell Reports] Researchers uncovered serine protease inhibitor Kazal type 1 (SPINK1) as a putative determinant of PDAC progression with a previously unrecognized role in epigenomic regulation.

[Cell Reports] Scientists combined single-cell and spatial genomics with patient-derived organoids and tumor samples to show how increased high mobility group-box protein 2 (HMGB2) availability represents a transcriptional addiction that fuels cell-cycle progression and growth.

[Cancer Letters] Investigators explored the role of Pbrm1 in tumorigenesis and progression of PDAC by using genetically engineered mouse models.

[British Journal of Cancer] Researchers showed that dual-oxygen pancreatic cancer organoids better capture basal–classical tumor heterogeneity, with hypoxia preserving aggressive basal-like cell states found in patient tumors.

[Diabetologia] The authors highlight recent discoveries in human pancreatic islet and β-cell biology, exploring how new models and technologies could advance strategies to restore insulin-producing cells in diabetes.

[FEBS Letters] Scientists take a β cell centric perspective to examine the evidence for autophagy/mitophagy across four clinically relevant diabetes categories and discuss the functional significance and complexity of these pathways in β cell failure.

[Erasca, Inc.] Erasca, Inc. announced that the US FDA has granted Fast Track Designation to ERAS-0015 for the treatment of patients with metastatic pancreatic adenocarcinoma.

[ADARx Pharmaceuticals, Inc.] ADARx Pharmaceuticals, Inc. announced that it has received Fast Track designation from the US FDA for onvuzosiran, an investigational small interfering RNA therapeutic candidate, for prophylaxis to prevent attacks of hereditary angioedema (HAE). The underlying cause of HAE is an abnormality in the kallikrein-kinin cascade resulting in increased bradykinin.

[Nature Communications] Focusing on the well-established angiocrine Wnt signaling-regulated liver metabolic zonation paradigm, researchers identified blood flow-induced hemodynamic stress as a biophysical sensor that governs the angiocrine expression profile of liver sinusoidal endothelial cells.