Targeting Pathogenic CD8+ Tissue-Resident T Cells with Chimeric Antigen Receptor Therapy in Murine Autoimmune Cholangitis

Treatment of Il12b-/-Il2ra-/- mice mice with PD-1-targeting CAR-T cells selectively depleted liver CD8+ memory T (Trm) cells and alleviated autoimmune cholangitis. Our work highlights the pathogenic role of CD8+ Trm cells and the potential therapeutic usage of PD-1-targeting CAR-T cells.