Time-Resolved Fate Mapping Identifies the Intestinal Upper Crypt Zone as an Origin of Lgr5+ Crypt Base Columnar Cells

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Using a kinetic reporter for time-resolved fate mapping and Fgfbp1-CreERT2 lineage tracing, the authors established that Fgfbp1+ cells were multi-potent and gave rise to Lgr5+ cells, consistent with their intestinal stem cell function.
[Cell]
AbstractGraphical Abstract