Newsletters

[iScience] Treatment of activated human CD8+ T cells from healthy donors with recombinant PCSK9 reduces surface LDL receptors and ICAM-1 expression, granzyme B secretion, and proliferation.

[Science Immunology] Researchers characterized γδ T cells in intestinal biopsies obtained from patients with ulcerative colitis and healthy donors using single-cell RNA sequencing, T cell receptor profiling, and mass cytometry.

[Texas Children’s Cancer & Hematology Center] Texas Children’s Cancer & Hematology Center is proud to celebrate faculty who have recently secured a total of over $3.2M in competitive research grants supporting innovative projects across cancer biology, immunotherapy, disease monitoring, and cancer susceptibility.

[University of Texas MD Anderson Cancer Center] In a first-in-human study, researchers at The University of Texas MD Anderson Cancer Center observed strong responses and early signs of antitumor activity in patients with difficult-to-treat non-Hodgkin lymphomas who received the novel cell therapy RB-1355.

[Haematologica] IL-7 robustly enhances human T cell proliferation, reduces exhaustion, and significantly improves blinatumomab’s cytotoxic efficacy in the presence of Src/BCRABL1 tyrosine kinase inhibitors.

[Plant Biotechnology Journal] Researchers introduced Salvia miltiorrhiza-derived nanoparticles (SDVLNs) to counteract ROS effects after myocardial infarction. They performed in vitro experiments to analyse the effects of SDVLNs on cardiomyocyte proliferation, migration, oxidative stress, and mitochondrial function.

[Basic Research in Cardiology] Piezo1 knockdown impaired exercise-induced reductions in cardiomyocyte apoptosis, survival benefits, and attenuation of fibrosis.

[Biological Research] Through employing an in vitro model replicating atrial cardiomyocytes during mitral regurgitation, scientists observed that shear stress increased Ca²⁺ oscillation and the amplitude of Ca²⁺ waves through extracellular Ca²⁺ influx.

[International Journal of Stem Cells] Investigators employed an microelectrode array chip incorporating transparent and conductive indium tin oxide electrodes to simultaneously monitor both morphological changes and field potential of human-induced pluripotent stem cell-derived cardiomyocytes.

[Skeletal Muscle] Researchers investigate the role of transient receptor potential vanilloid 1 (TRPV1) in cardiotoxin-induced skeletal muscle injury and regeneration, focusing on its impact on macrophage polarization and myogenesis.

[Scientific Reports] Scientists investigated the contribution of αv integrins to both arterial wall stiffness and vascular smooth muscle cell stiffness

[International Journal of Molecular Medicine] Investigators highlighted the frequently underappreciated role of vascular smooth muscle cells in sepsis‑induced vasodilation and provided a comprehensive and systematic elucidation of the associated pathophysiological mechanisms.