Newsletters

[Lynk Pharmaceuticals Co., Ltd.] Lynk Pharmaceuticals Co., Ltd. announced that the New Drug Application (NDA) for its core product, zemprocitinib capsules, for the treatment of moderate-to-severe atopic dermatitis, has been formally accepted by the Center for Drug Evaluation of the China National Medical Products Administration (NMPA).

[Nature Communications] Investigators unveiled that autonomously generated hypoxic environment-induced metabolic adaptation drives the transition from coalesced spheroids to a planarized structure in skin organoids through the following three levels.

[Molecular Therapy] Scientists developed a novel topical formulation of the peroxisome proliferator-activated receptor gamma (PPARγ) agonist rosiglitazone to enhance regenerative healing in irradiated skin.

[Biofabrication] Researchers developed a customized anti-shrinkage device designed to physically constrain the substitute while remaining compatible with the established fabrication process of plastically compressed dermo-epidermal skin substitutes.

[International Journal of Biological Macromolecules] The authors found that procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), also known as lysyl hydroxylase 2, may be a key component linking epidermal and dermal dysfunctions during the development of psoriasis.

[ACS Synthetic Biology] Investigators indicated that mucin-type CF15 series collagens have excellent potential as an alternative medicine for the treatment of atopic dermatitis and other skin-related inflammatory diseases.

[Journal of Ethnopharmacology] Scientists evaluated a flavonoid-rich fraction of Phyla nodiflora derived from the solvent-free microwave hydrodiffusion and gravity extraction for its protective effects against particulate matter-induced oxidative damage.

[Journal of Applied Toxicology] Researchers aimed to investigate the effects of clomiphene citrate on melanoma cell viability and metabolism, cell cycle progression, migratory capacity, and the modulation of genes involved in epithelial–mesenchymal transition.

[NPJ Regenerative Medicine] Investigators provide an overview of the processes for melanocyte stem cell quiescence and activation, and highlight current research on the mechanisms of hair graying.

[iScience] Scientists examine the Piezo1-PI3K/Akt signaling axis as a putative convergent context-dependent mechanotransduction node, through which multiple mechanical inputs may be transduced into intracellular biochemical cascades.

[Cell Communication and Signaling] Researchers identified IL-9 as a key regulator of Treg activation via a novel Sirt1-STAT5 epigenetic pathway, which promotes tissue repair after myocardial infarction.

[Immunity] Investigators showed that Foxp3 cooperates with BATF to direct cis-regulatory programs and gene expression essential for the differentiation of immunosuppressive effector Treg cells.