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[Texas Children’s ] Dr. Rui Yang has been awarded the Burroughs Wellcome Fund Career Award for Medical Scientists. Yang’s research focuses on understanding the genetics of immune reactions that underlie severe infectious and autoimmune diseases and working to identify how inherited variations in immune system pathways contribute to susceptibility to infection and immune dysfunction.

[Mount Sinai Today Blog] A gift from philanthropists Judith and Stewart Colton will establish a Colton Center for Autoimmunity within the Marc and Jennifer Lipschultz Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai. This move expands research focused on earlier detection, precision treatment, and disease prevention.

[Nature Medicine] This Phase I/II trial evaluated an investigational maternal hexavalent polysaccharide−protein conjugate GBS vaccine in non-pregnant females and pregnant participants and their infants.

[Science] Investigators constructed a single-cell 3D genome atlas of human tonsil cells and characterized changes in multiscale 3D genome features during germinal center B cell development.

[Molecular Cancer] Through novel observational methods focused on human living and fixed tissue, scientists profiled the spatial and molecular features of microsatellite stable colorectal liver metastasis and the surrounding liver microenvironment.

[Nature Immunology] Researchers presented a comprehensive analysis of T cells from human lungs. They mapped the pathogen specificity of more than 87,000 lung T cells across 40 individuals, the majority of whom harbored memory T cells specific to multiple pathogens.

[Nature Communications] Scientists showed, in a nested case-control study within a low-risk, population-based pregnancy cohort, that an abnormal immune adaptation in mothers’ blood precedes spontaneous preterm births (sPTB) by weeks to months and discriminates sPTB cases from term controls.

[Cell Reports] Researchers demonstrated that human GBP4 promotes the containment of intracellular Mtb by enhancing autophagy. We identify progranulin (GRN) as a major GBP4-interacting protein and a key regulator of autophagy in Mtb-infected human macrophages.

[Nature Reviews Cancer] The authors examine the molecular mechanisms by which DNA damage response (DDR) defects potentiate immunotherapy, including recent advances in DDR-targeted combination strategies.

[Autoimmunity Reviews] Scientists summarize how apoptosis, necroptosis, pyroptosis, and ferroptosis operate as an interlocking network in autoimmune microenvironments, frequently co-existing as context-dependent mixed-death states driven by shared triggers such as cytokines, PRR ligands, and oxidative stress.

[Metabolism Clinical and Experimental] Researchers studied 63 individuals undergoing partial pancreatectomy who underwent preoperative OGTT with model-based assessment of β cell function and provided pancreatic tissue for ex vivo islet isolation and glucose stimulation.

[Cancer Letters] Scientists established Foxa1-orchestrated enhancer reprogramming as a fundamental mechanism of gemcitabine resistance and unveil a promising epigenetic therapy to restore treatment efficacy in PDAC.