Newsletters

[Advanced Science] Scientists validated the biological function of HOXC11 in colorectal cancer (CRC) proliferation and metastasis and established its clinical relevance in CRC.

[Cell Reports Methods] Investigators established a scalable, microarrayed 3D human intestinal organoid platform enabling high-throughput, single-organoid-resolution phenotyping of cytokine-induced epithelial injury and recovery.

[Cancer Letters] Researchers demonstrated that PEBP4 was upregulated in colorectal cancer (CRC) specimens and was also elevated in the serum of CRC patients.

[Communications Biology] Scientists reported that the expression of collapsin response mediator protein 4 (CRMP4) is highly expressed in colorectal cancer cells carrying wild-type tumor protein p53 (p53) under hypoxic conditions and can be compromised by p53 or HIF1α knockdown.

[Cancer Gene Therapy] Vacuolar protein sorting-associated protein 35 (VPS35) was identified as a potential predictive biomarker for chemotherapy response in gastric cancer.

[Experimental Cell Research] Investigators aimed to elucidate the role and mechanism of FAM105A in gastric cancer (GC) progression. FAM105A was significantly overexpressed in GC tissues, and its high expression correlated with advanced TNM stage and poor prognosis.

[Trends in Molecular Medicine] The authors describe how gut microbiota affects drug metabolism on a mechanistic level and outline the interactions of specific microbes and their products with chemo-, targeted, and immunotherapies employed in colorectal cancer.

[Amsterdam UMC] KWF announced 34 research projects that will receive funding in its latest round — including 8 projects involving Cancer Center Amsterdam (CCA) researchers.

[Nature] Scientists established mosaic analysis with double markers technology in mouse embryonic stem cells to probe radial glial progenitor lineage progression in a self-organizing cortical organoid system.

[Developmental Cell] The authors generated elongating heart organoids from hiPSCs that undergo coordinated elongation and looping-like curvature, resembling early cardiac morphogenesis.

[Journal of Advanced Research] Researchers established a high-fidelity mouse skin organoid platform to simulate clinically relevant stressors and identify the core regulatory components of the regenerative program.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators developed an Epstein–Barr virus human tonsil organoid model to evaluate key B cell states and antiviral responses, including after primary infection.