Newsletters

[Signal Transduction and Targeted Therapy] Researchers applied 3D patient-derived, metastatic human mammary organoids to model apoptosis resistance, necroptosis, and inflammatory signaling using single-cell CITE-sequencing, time-lapse live cell brightfield, and immunofluorescent confocal microscopy.

[Cell Reports] Investigators presented an extensive catalog of mutational signatures induced by a panel of environmental carcinogens using human tissue-derived organoids coupled with high-fidelity duplex sequencing

[Journal of Translational Medicine] Scientists established a robust and clinically validated patient-derived organoid platform for hepatic malignancies that accurately predicts patient-specific drug responses.

[Genes & Development] Researchers generated cerebellar organoids from expanded potential stem cells and performed integrated single-cell transcriptomic and DNA methylation analyses, revealing discrete human rhombic lip progenitor populations whose developmental programs align with group 3- and group 4-associated lineages.

[Scientific Reports] Investigators developed a novel cellular model of multiple spheroids derived from neuronal SH-SY5Y cells. They observed that poly-D-lysine coating can induce formation of a population of spheroids.

[NPJ Microgravity] In order to cultivate 3D models of spheroids in microgravity, scientists developed and used an acoustic bioreactor to trap levitating cellular organoids in a liquid cell culture medium.

[Seminars in Cancer Biology] The authors summarize the diverse protocols currently used for glioblastoma organoid derivation and long-term maintenance, focusing on the recapitulation of microenvironmental traits.

[Cancer Cell] Using multiplexed single-cell proteomics to analyze 50 tumor microenvironment-associated proteins across treatment-naive triple-negative breast cancer specimens, we discovered that CSCs drive differentiation and expansion of regulatory T cells via extracellular vesicle-mediated paracrine signaling.

[Cell Stem Cell] Researchers revealed four distinct leukemic stem cell types with unique vulnerabilities and propose biomarker-guided treatment strategies that complement genetic profiling to overcome venetoclax resistance.

[Cell Stem Cell] Scientists showed that leukemic stem cells in acute myeloid leukemia exhibit elevated ketogenesis, driven by fatty acid oxidation, to produce β-hydroxybutyrate.

[Nature Communications] Investigators showed that recurrent L122R mutation in the DNA-binding site of the Myogenic Differentiation 1 (MYOD1) transcription factor increases cancer stem cell frequency in aggressive Spindle cell/sclerosing rhabdomyosarcoma.

[Nature Communications] Researchers found that increased matrix stiffness promotes radioresistance in glioblastoma and maintains tumor cell hierarchies.