Newsletters

[ Anixa Biosciences, Inc.] Anixa Biosciences, Inc. announced that the Canadian Intellectual Property Office has issued a Notice of Allowance for a patent covering key aspects of Anixa's ovarian cancer vaccine technology. Anixa's ovarian cancer vaccine is based on immunizing against AMHR2, a protein expressed in normal ovaries prior to menopause and also aberrantly expressed in certain types of ovarian cancer.

[The Salk Institute] Three Salk faculty members, Drs. Sung Han, Daniel Hollern, and Graham McVicker, have been chosen as Keck Scholars, alongside corresponding graduate students as Keck Fellows, in a special W. M. Keck Foundation Bridge Funding Initiative.

[Nature Immunology] Researchers used single-cell RNA sequencing of resting and CD3+CD28 antibody-stimulated T cells from lymphoid and mucosal tissues of organ donors to investigate age-dependent mechanisms for functional regulation of human memory T cells. Their findings revealed key mechanisms controlling T cell functional states in early life.

[Nature Reviews Immunology] Scientists highlight emerging correlates of response to adoptive cell transfer and novel strategies that integrate tumor immunology, cancer genomics, computational biology, and T cell engineering for the development of next-generation cellular immunotherapies.

[Molecular Cancer] The authors summarize current evidence on the compositional alterations of viruses, fungi, and archaea across the major types of gastrointestinal cancer, including colorectal, hepatocellular, gastric, pancreatic and esophageal/oral cancers.

[Cell Reports] Investigators summarize the current knowledge of the pathways that regulate the generation and maintenance of high-affinity immunoglobulin E (IgE) responses. Theyt focus on how IgE immunity diverges from the classical germinal center-centered paradigm for the generation of long-lived B cell responses established during acute infection or protein immunization

[Cell Reports] Researchers showed that cortisol reshapes the transcriptional landscape of human CD8 T cells through cooperation between the glucocorticoid receptor (GR) and RUNX transcription factors. They identified RUNX3 as a critical non-canonical GR partner and uncover a mechanism by which endogenous glucocorticoids drive CD8 T cell dysfunction in human cancer.

[Cell Biomaterials] Scientists describe the immune-related functions of canonically non-immune cells and their interactions with biomaterials. They provide evidence for how canonically non-immune cells respond to biomaterials in immunomodulatory ways and how incorporating these cells, their components, or their products into biomaterials influences the immune system.

[Elife] Using single-cell sequencing and multi-omics data, researchers characterized BRCA1/2 mutation-associated transcriptional programs, immune cell composition, and functional alterations in T cells, investigating the molecular and immune architecture of BRCA-mutant lung adenocarcinoma patients.

[Cell Metabolism] Research has defined that the gut microbiota are essential for successful cancer immunotherapy, with specific microbes and associated metabolites linked to therapeutic outcomes.

[Immunity] The authors synthesize recent evidence from healthy individuals and disease contexts, focusing on cancer and autoimmunity, detailing how acute bouts and consistent training reshape the mobilization, fate, and function of innate and adaptive immune cells.

[Nature Immunology] Scientists examine how cellular and humoral factors in blood, tissues and/or breast milk calibrate immune development, and how postnatal microbial colonization and environmental exposures further refine immune function in a tissue- and time-dependent manner.