Newsletters

[Nature Communications] Investigators showed that H3K9me3 deposition is dynamic during epidermis morphogenesis and essential for lineage diversification.

[Allergy] Short-term sodium dodecyl sulfate exposure rapidly disrupts human skin barrier integrity through oxidative stress-driven suppression of structural/immune mediators and activation of stress/remodeling pathways.

[iScience] Researchers providesa greater understanding of, and potential strategies to refine, essential human fibroblast culture models.

[Nature Communications] Scientists identified the small MAF family transcription factor MAFG as a critical regulator of MITF activity and melanoma cell state plasticity.

[Cancer Research] The authors found that both compounds demonstrated potent anti-proliferative activity against NRAS-mutated melanoma cell lines and robust anti-tumor activity against preclinical melanoma models.

[Journal for Immunotherapy of Cancer] This Phase I/II, open-label, multicenter study evaluated drug combinations in patients with metastatic melanoma and cutaneous squamous cell carcinoma. Pegenzileukin was given at two dose levels during dose escalation and the recommended Phase II dose during dose expansion, while cemiplimab was given at a dose of 350 mg.

[Cell Death & Differentiation] Researchers demonstrated a novel facet of GSDME as an epigenetic modifier that promotes melanoma development through the regulation of the centriole biogenesis regulator PLK4.

[Bioscience Trends] The authors systematically elaborate the cellular and molecular mechanisms underlying skin photoaging. This review also details the pivotal roles of and reciprocal crosstalk among fibroblasts, keratinocytes, melanocytes, and various immune cells.

[Abeona Therapeutics, Inc.] Abeona Therapeutics, Inc.announced activation of the Children’s Hospital of Philadelphia as the sixth Qualified Treatment Center for the administration of ZEVASKYN gene-modified cellular sheets.

[Nature Metabolism] Researchers discovered that deleting the cardiolipin-synthesizing enzyme protein tyrosine phosphatase mitochondrial 1 (PTPMT1) in T cells predisposes mice to colitis due to impaired Treg cell function in the absence of dysbiosis.

[Immunology] The authors review preclinical and clinical applications of Treg-based therapies, including adoptive Treg transfer, low-dose IL-2, and CAR-Treg therapy. They discuss their effectiveness in modulating immune responses across diverse pathological contexts.

[Clinical Reviews in Allergy & Immunology] Scientists dissect the multi-layered mechanisms through which dendritic cells orchestrate immune tolerance, spanning cytokine signaling, metabolic reprogramming, epigenetic remodeling, and migratory dynamics.