Hepatitis B Virus Surface Antigen Drives T Cell Immunity through Non-Canonical Antigen Presentation in Mice

Using preclinical mouse models, investigators showed that, following HBsAg expression, the intrahepatic Batf3⁺XCR1⁺CCR7^– conventional dendritic cell subset cDC1 presents HBsAg by MHC-I cross-dressing, driving CD8⁺ T cell response.