Newsletters

[Verdiva Bio Limited] Verdiva Bio Limited announced the completion of enrollment for its Phase IIb EVOLVE-2 clinical study of VRB-101, a once-weekly oral, cAMP-biased, GLP-1 peptide analog candidate for body weight reduction in people with overweight or obesity.

[Science] Investigators implanted tissue-like, stretchable electronics during organogenesis of human pancreatic organoids, enabling months-long, single cell–resolved electrophysiology.

[Cell Death & Disease] Researchers reported that Ripk1 expression is increased in islets from aged non-obese diabetic mice and β cells from T1D donors, suggesting that RIPK1 may drive cytokine- and autoimmune-mediated β cell demise in T1D.

[Cell Reports Medicine] Scientists described a lipid nanoparticle platform for β cell-enriched mRNA delivery that can be further augmented by conjugation to enhanced glucagon-like peptide-1.

[Nature Communications] Investigators identified a maturation-dependent requirement for iron in mouse and human β cells. Using chemical chelation and genetic disruption of transferrin receptor (TFRC)-mediated uptake, they showed that immature β cells depend on iron during metabolic transition to functional maturity.

[Science Advances] Researchers searched for oncogenes activated by copy number increases using whole-genome sequencing data of 535 PDACs. They found that gains of 1q were the second most common gain, occurring in 213 (39.8%) of PDACs.

[Diabetes] Scientists investigated the contribution of pancreatic fibroblasts to β-cell dysfunction and type 2 diabetes mellitus (T2DM) progression. They used single-cell sequencing technology and in vitro experiments to investigate the mechanisms by which bariatric surgery ameliorates T2DM.

[Gastroenterology] Investigators uncovered the plasticity of PDAC tumor cell states and interactions with the tumor microenvironment that are modified during chemotherapy of unresectable advanced PDAC.

[JCI Insight] Researchers investigated the bidirectional crosstalk between sympathetic nerves and cancer-associated fibroblasts in human and mouse pancreatic tumors.

[Diabetologia] Scientists examine the literature regarding a potential common aetiological role of pancreatic fibrosis in the pathogenesis of type 3c, type 2, and type 1 diabetes.

[Canadian Affairs] Researchers at the University of British Columbia and B.C. Children’s Hospital Research Institute have recently discovered how to use stem cells to create the immune cells needed for effective cell therapy.

[Proceedings of The National Academy of Sciences of The United States of America] The authors demonstrated that the nonoxidative pentose phosphate pathway, mediated by transketolase and transaldolase, is critical for CD8+ T cell activation, proliferation, and memory formation by maintaining NADPH homeostasis.