Newsletters

[iXCells Biotechnologies] iXCells Biotechnologies announced it has entered an international collaboration with Rosebud Biosciences, Kantify, and Incite to evaluate off-target chemotherapeutic toxicities in patient-specific organoids

[Molecular Cancer] Investigators developed two organoid models for pediatric low-grade gliomas, which, after engraftment into mice, exhibited low-grade features.

[Nature Protocols] Scientists presented a detailed protocol for the generation and maintenance of pediatric patient-derived tumoroids and pediatric patient-derived xenograft tumoroids directly from primary ependymoma and medulloblastoma tumor specimens,

[Science Advances] Researchers demonstrated that primary organoids derived from human small intestine and rectal tissues support productive infection by both clade I and II monkeypox virus isolates.

[Cell Death & Disease] The authors highlighted that ABT-737, through BCL-xL inhibition and synergy with ER stress inducers, triggers ovarian cancer death, offering promising strategies for overcoming chemoresistance in relapsed ovarian cancer.

[Bioscience Trends] Scientists established a hiPSC-derived multilineage hepatic organoid system that robustly supports the complete hepatitis B virus life cycle, including viral entry, replication, covalently closed circular DNA formation, antigen secretion, and production of infectious progeny virus.

[Scientific Reports] Researchers generated airway organoids from both clinical donor tissues and commercially available nasal epithelial cells and showed in comparative analyses with whole lung tissue that these organoids are comparable in terms of cell composition.

[Advanced Science] Investigators examine progress toward bone organoid development within the broader landscape of soft-tissue organoid innovation and then use diabetes-associated skeletal disorders as a representative case study.

[Cancer Immunology Research] Using single-cell and spatial transcriptomes, scientists identified at the single-cell level, a subpopulation of macrophages related to T cell expansion during immunotherapy, characterized by high temperature requirement A1 (HTRA1) high expression and correlated with clinical and immunotherapy outcomes in TNBC.

[Cell Death Discovery] Researchers investigate how intratumoral lactate accumulation affects NK cell function in breast cancer, a neoplasm characterized by elevated glycolytic flux.

[Journal of agricultural and food chemistry] Investigators determine Citrulline’s impact on milk fat synthesis and clarify its mechanism. They initially examined reticulon 3 (RTN3) expression in the mammary glands of dairy cows with high and low milk fat contents.

[Clinical and Experimental Immunology] Scientists showed that nebivolol reinvigorates CD4⁺ and CD8⁺ T cells following repeated activation, restoring their cytotoxic function against breast cancer cells in vitro.