Unraveling CD8 Lineage Decisions Reveals That Functionally Distinct CD8⁺ T Cells Are Selected by Different MHC-I Thymic Peptides

The authors reported that encoding CD8 co-receptors in both Cd4 and Cd8 gene loci modulates major histocompatibility complex class I T cell antigen receptor signaling duration to generate all potential CD8+ T cell subsets.