Newsletters

[iScience] Scientists discovered that inhibiting MYH9 or knocking down its gene significantly impairs angiogenesis, vasculogenesis and vascular endothelial cells functions including migration and tube formation.

[Nature Communications] Researchers investigate the impact of vascular C-type natriuretic peptide/guanylyl cyclase-B signaling on the development of pulmonary arterial hypertension.

[NPJ Breast Cancer] The authors summarize animal models utilized to study breast cancer metastasis, including mutagen-induced and genetically engineered mouse models, cell line-based syngeneic and xenograft models, patient-derived xenografts, as well as rat and zebrafish models.

[NPJ Breast Cancer] Using validated hypoxia signatures and TNBC cell models, researchers showed that TPM3 is induced in physiologically relevant hypoxic conditions in a HIF-1–dependent manner.

[Nature Communications] Scientists presented a programmable nanomicelle platform that reconfigures myeloid immunity to combat both primary and metastatic breast cancer.

[Oncogenesis] In vitro experiments demonstrated that intermediate filament family orphan 1 (IFFO1) overexpression suppresses the proliferation, invasion, and epithelial-mesenchymal transition of breast cancer cells by inhibiting mitochondrial fission and fatty acid synthesis.

[Nature Communications] Scientists established a West Nile virus encephalitis model using human cerebral organoids, generated with male iPSCs.

[Gut] The authors evaluated iPSC-induced human liver, intestinal and brain organoids as platforms for Hepatitis E virus infection and replication.

[Trends in Cancer] Human organoids aim to emulate organ microenvironments in vitro and, when cocultured with cancer cells, can provide complementary models. These ‘chimeroids’ may enable scalable studies of cancer–microenvironment interactions and support genetic and pharmacological screens to discover new targets.

[Trends In Biotechnology] The authors survey recent progress at the interface of organoid research and computational approaches, discuss key challenges on both fronts.

[Cell Stem Cell] Scientists established a biobank of patient-derived organoids (PDOs) from matched primary tumors, adjacent normal tissues, and lymph node metastases. Integrated analyses demonstrate that these PDOs preserved tumor-specific molecular signatures and recapitulated epigenetic remodeling during disease evolution.

[Oncogene] Researchers uncovered a novel tumor-suppressive role for cereblon (CRBN), a substrate receptor of the CRL4CRBNE3 ubiquitin ligase complex, in modulating prostate cancer metastasis through regulation of 6-phosphogluconate dehydrogenase (6PGD).