Newsletters

[Signal Transduction and Targeted Therapy] Researchers investigated the mechanistic role of parathyroid hormone–related protein_1-34 in pulmonary fibrosis both in vitro and using in vivo models and proposed different strategies for blocking idiopathic pulmonary fibrosis progression.

[Nature Communications] Using well-established acute lung injury and sepsis models, scientists demonstrated that brain-derived neurotrophic factor, a key neurotrophic factor, is impaired in pulmonary epithelial cells and negatively correlates with the inflammatory response.

[Nature Communications] Investigators performed a drug screening with an in vitro pulmonary fibrosis model using fibroblast-dependent alveolar organoids derived from hiPSCs and identified p300/CBP inhibitors as candidate therapeutic agents.

[RMD Open] To assess anlotinib’s therapeutic effects, researchers established a MAILD mouse model and a neutrophil extracellular trap (NET)-induced human alveolar epithelial cell model.

[European Journal of Medical Research] Scientists investigated whether airway epithelial cell-derived exosomes on lipopolysaccharide-induced Acute respiratory distress syndrome model regulate macrophage polarization via the GATA1 pathway.

[Cell Discovery] The authors showed that ZDHHC14 as the key palmitoyltransferase catalyzing ASCT2 palmitoylation at conserved Cys39 and Cys48 residues, promoting lysosomal degradation of this glutamine transporter, whereas ABHD17B functions as a depalmitoylase to stabilize ASCT2.

[Cell Death & Disease] Investigators identified key enzymes in the serine synthesis pathway, namely PHGDH, PSAT1 and PSPH, as well as the serine transporter SLC1A4, which are significantly overexpressed in lung cancer and correlate with poor patient prognosis.

[Journal of Translational Medicine] Scientists identified FCRLB as a key gene influencing lung cancer prognosis via transcriptomic gene screening, and elucidated its unique roles in tumor cells.

[Cancer Cell International] Cigarette smoke extract significantly enhanced the proliferation, migration, and invasion capacities of A549 and H1299 cells while inducing alterations in epithelial-mesenchymal transition markers and cellular morphology.

[Scientific Reports] Researchers identified Protein Phosphatase 1 Regulatory Subunit 14C (PPP1R14C), an endogenous inhibitor of Protein Phosphatase 1, as a pivotal oncogenic driver in Lung squamous cell carcinoma.

[Advanced Healthcare Materials] Scientists examine the role of phytochemical drugs and the current status of phytochemical delivery using various nanocarriers for treating lung inflammation and fibrosis.

[Discover Oncology] Investigators summarize the categories of lung cancer biomarkers, evaluates recent advances in detection technologies, and assesses their clinical potential and associated challenges.