Newsletters

[Cell Communication and Signaling] Researchers identified IL-9 as a key regulator of Treg activation via a novel Sirt1-STAT5 epigenetic pathway, which promotes tissue repair after myocardial infarction.

[Immunity] Investigators showed that Foxp3 cooperates with BATF to direct cis-regulatory programs and gene expression essential for the differentiation of immunosuppressive effector Treg cells.

[Communications Biology] Emerging research suggests three plausible hypotheses for the role Tregs have in maintaining immune homeostasis in axial spondyloarthritis. The authors explore these hypotheses across gut, skin, and joint to contextualize extra-articular manifestations and disease heterogeneity.

[Journal for Immunotherapy of Cancer] Investigators studied the effects of HFB301001 treatment on tumor-infiltrating T cells, safety in cynomolgus monkeys, and immune activation in clinical samples. HFB301001 is a low-affinity, non-competitive antibody that binds OX40 without disrupting OX40L interaction.

[Acta Pharmacologica Sinica] Investigators identified a novel dual CDK8/19 inhibitor RO8323 and systematically dissected the mechanism of CDK8/19-mediated immunoregulation. In the in vitro and in vivo experimental settings, they demonstrated that RO8323 selectively enhanced Treg differentiation while suppressing effector T.

[Cancer Immunology Research] Scientists identified the extracellular adenosine 5-triphosphate receptor P2RX7 as a key regulator of Treg function in lung tumors. They suggest that targeting P2RX7 may constitute a strategy to improve lung cancer treatment by alleviating Treg-mediated immune suppression.

[Science Immunology] Using a screen of mitochondrial inhibitors, researchers identified copper chelators and ionophores as modulators of Treg cell energetic state.

[Fortitude Biomedicines, Inc.] Fortitude Biomedicines, Inc. announced today that the Company’s lead program is a first-in-class T cell targeting bispecific antibody for the potential treatment of Axial Spondyloarthritis.

[Nature Metabolism] Researchers showed that irisin, an exercise-induced myokine, modulates adipose tissue inflammation by increasing IL-33 production and preserving ST2+ Tregs in white adipose tissues.

[Cell Death & Differentiation] Scientists discuss HECT E3 ubiquitin ligases involved in inflammation and how their ubiquitin-modifying functions influence immune signaling and inflammatory disease progression.

[Signal Transduction and Targeted Therapy] Immune modulatory vaccines (IMVs) are an emerging class of immunotherapies designed to expand anti-Tregs that selectively target immunosuppressive elements within the TME. IMVs remodel suppressive cellular networks, enhance immune infiltration, and amplify endogenous tumor-specific immunity.

[Gut] Scientists investigated the role of the oxidative stress sensor protein Pirin as a critical mediator of inflammation in hepatocellular carcinoma progression.