Newsletters

[NPJ Biofilms and Microbiomes] Researchers profiled mammary single-cell transcriptomes in goats with ruminal dysbiosis-induced mastitis, complemented by ruminal metagenomic and untargeted metabolomic analyses of rumen fluid and serum.

[Karolinska Institutet] The Department of Oncology‑Pathology at Karolinska Institutet has announced the recipients of the 2026 Blue Sky Grant, an internal funding call aimed at supporting innovative, cross‑disciplinary research led by early‑career researchers.

[DFCI] The US FDA has approved a new therapy regimen for patients with “double-positive” metastatic breast cancer based on results of the Phase III PATINA study led by Dr. Otto Metzger, Associate Medical Director of International Strategic Initiatives at Dana-Farber Cancer Institute.

[Nature Communications] Integrating single-cell RNA sequencing, spatial transcriptomics, and genomics across 28 patients with synchronous ductal carcinoma in situ and invasive breast carcinoma, scientists delineated the spatial-molecular hierarchy of this transition.

[Oncoimmunology] The authors summarize and critically discuss the circulating immune landscape of human breast cancer, whenever possible comparing across disease subtypes, stages, and treatment outcomes.

[Cell Death & Disease] Researchers investigated the role of SLC22A3, which is enriched in mesenchymal (MES) subtype tumors and positively correlates with markers of tumor stem cells. High SLC22A3 expression in MES-TNBC cells modulates serotonin uptake and metabolism, conferring ferroptosis resistance.

[Cell Death Discovery] Scientists investigated the function of LINC01929 in breast cancer through a combination of in vitro and in vivo experiments, bioinformatics analysis, RNA pull-down mass spectrometry, and clinical tissue validation.

[Experimental & Molecular Medicine] Using a breast-specific CYP4Z1-transgenic MMTV-PyMT mouse model, researchers show that CYP4Z1 notably accelerates tumor initiation, enlarges tumor size, promotes metastasis, and expands tumor-initiating cell populations.

[Molecular and Cellular Biology] Scientists highlight recent progress in our understanding of how transcriptional regulators mediate mammary gland development, mammary oncogenesis and maintenance of breast cancer stem cells, breast cancer phenotype, metastasis, and efforts to target transcription factors as a therapeutic approach in breast cancer.

[Nature] Researchers developed a compendium of the ten most frequent human chromosome-arm-level alterations in basal-like breast cancer, a disease type that is driven by large copy-number alterations. Using CRISPR-KOALA, they screened the mouse orthologues of 3,752 genes on these arms and identified 90 cancer driver genes.

[Journal of Advanced Research] Researchers identified TNBC Promoting LncRNA 1 (TPL1) as a functionally relevant lncRNA associated with TNBC growth, invasion, and molecular regulatory programs.

[Science Advances] Scientists uncovered an unanticipated somatic role for the synaptonemal complex protein SYCP1, previously regarded as strictly meiosis specific, in a broad spectrum of human cancers including breast cancer.