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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
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Circ-ABCA1 Promotes Breast Cancer Stem Cell-Mediated Malignant Progression by Modulating Mir-33a-5p/EIF4A3 Axis
[Clinical and Experimental Medicine] Researchers demonstrated that circ-ABCA1 promotes breast cancer stem cell-mediated malignant progression by modulating miR-33a-5p/EIF4A3 axis.
PIEZO1 Is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A-SLC7A11 Axis-Mediated Ferroptosis Defense
[Advanced Science] Researchers uncovered the mechanosensor PIEZO1 as a key factor in promoting AML progression and maintaining LSC stemness by HIF1A-SLC7A11 axis-mediated ferroptosis defense.
A Ketogenesis-Ferroptosis Axis Maintains Leukemic Stem Cell Survival and Leukemia Progression
[Cell Stem Cell] Investigators showed that leukemic stem cells in acute myeloid leukemia exhibit elevated ketogenesis, driven by fatty acid oxidation, to produce β-hydroxybutyrate.
Leukemic Stem Cell Subtypes Determine Venetoclax Resistance and Therapeutic Vulnerabilities in AML
[Cell Stem Cell] By molecular and functional profiling of leukemic stem cells (LSC) from >150 patients, researchers identified four LSC subtypes. These mirror distinct hematopoietic lineage stages, which determine the expression ratio between the venetoclax target BCL-2 and resistance-inducing proteins MCL-1 and BCL-xL.
Cancer Stem Cells Orchestrate Immune Evasion through Extracellular Vesicle-Mediated Non-Canonical Signaling Pathways
[Cancer Cell] Using multiplexed single-cell proteomics to analyze 50 tumor microenvironment-associated proteins across treatment-naive triple-negative breast cancer (TNBC) specimens, scientists discovered that CSCs drive differentiation and expansion of regulatory T cells via extracellular vesicle-mediated paracrine signaling.
Transposable Elements Shape Stemness in Normal and Leukemic Hematopoiesis
[Nature Genetics] By identifying chromatin variants from accessibility measurements across leukemia stem cells, hematopoietic stem cells, and downstream progeny, researchers identified transposable elements as genetic determinants of primitive versus mature populations.
Citraconate Preserves T Cell Stemness and Antitumor Immunity
[Science Immunology] Researchers identified citraconate, an itaconate isomer, as a metabolite markedly depleted in CD8 T cells subjected to chronic antigen stimulation or hypoxic conditions. Citraconate supplementation preserves stemlike characteristics, attenuates ferroptosis, and potentiates T cell–mediated antitumor immunity.
TENT5A Maintains MYC mRNA Stability to Enhance Osteosarcoma Stemness
[Cancer Research] The authors showed that cytoplasmic mRNA poly(A) sustains MYC activation in osteosarcoma. Multiomics profiling and single-cell transcriptomics identified TENT5A, a noncanonical RNA-binding poly(A) polymerase, as selectively upregulated in MYC-activated tumors and enriched in proliferative, stem-like populations.
Plasticity, Signaling, and Metabolic Rewiring in Melanoma Persister Cells
[Communications Biology] Compared with parental melanoma cells and other phenotypic variants such as melanoma stem cells or senescent cells, persisters show altered and reversible differentiation programs, distinct metabolic adaptations, and rewired signaling networks, all affected by the tumor microenvironment, but remain poorly understood.
Multi-Omics Analysis of Pediatric Minimally Differentiated Acute Myeloid Leukemia Reveals RUNX1-Driven Stemness and Chemoresistance
[Leukemia] Scientists conducted a comprehensive multi-omics analysis of 23 pediatric differentiated acute myeloid leukemia cases and compared them with 1483 leukemia samples. Functional analyses showed stem cell-like transcriptional features and reduced expression of genes related to oxidative phosphorylation and ribosomal pathways.
KDM4B/DHX9 Promotes Chemoresistance in Small-Cell Lung Cancer through the MYCN-Driven Signaling Pathway
[Oncogene] Researchers identified KDM4B as a key driver of chemoresistance, with immunohistochemical analysis revealing its elevated expression in chemoresistant tissues from small cell lung cancer patients. KDM4B promoted chemoresistance through the Hedgehog pathway by enhancing cell proliferation and stemness.
New Awards and Publications Showcase Achievements from Staff at the National Comprehensive Cancer Network
[NCCN® (EurekAlert)] The National Comprehensive Cancer Network®(NCCN®) announced several recent external awards and publications honoring the work of NCCN’s dedicated staff. The distinctions focused on scientific research, policy efforts, patient information, and system improvements.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
