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Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
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RUNX1 Recruitment of GCN5 in Keratinocytes Upregulates ICOSLG and Promotes T Cell Activation in the Psoriasis Microenvironment
[Experimental & Molecular Medicine] Single-cell RNA-sequencing and multiplex immunohistochemistry analyses demonstrated upregulated expression of inducible T cell co-stimulator ligand (ICOSLG) and RUNX1 in psoriatic keratinocytes.
A Physiologically Relevant In Vitro 3D Melanoma Skin Model for Targeted Therapy Assessment
[Biofabrication] Investigators developed and assessed a physiologically relevant scaffold-free 3D melanoma model that mimics the morphological and functional features of the melanoma lesion.
Vanda Pharmaceuticals Announces Orphan Drug Designation in Japan for Imsidolimab in Generalized Pustular Psoriasis
[Vanda Pharmaceuticals Inc.] Vanda Pharmaceuticals Inc. announced that Japan's Ministry of Health, Labour and Welfare has granted orphan drug designation to imsidolimab, a high‑affinity humanized immunoglobulin G4 monoclonal antibody, for the treatment of generalized pustular psoriasis.
RUNX1 Recruitment of GCN5 in Keratinocytes Upregulates ICOSLG and Promotes T Cell Activation in the Psoriasis Microenvironment
[Experimental & Molecular Medicine] Single-cell RNA-sequencing and multiplex immunohistochemistry analyses demonstrated upregulated expression of inducible T cell co-stimulator ligand (ICOSLG) and RUNX1 in psoriatic keratinocytes.
A Physiologically Relevant In Vitro 3D Melanoma Skin Model for Targeted Therapy Assessment
[Biofabrication] Investigators developed and assessed a physiologically relevant scaffold-free 3D melanoma model that mimics the morphological and functional features of the melanoma lesion.
Vanda Pharmaceuticals Announces Orphan Drug Designation in Japan for Imsidolimab in Generalized Pustular Psoriasis
[Vanda Pharmaceuticals Inc.] Vanda Pharmaceuticals Inc. announced that Japan's Ministry of Health, Labour and Welfare has granted orphan drug designation to imsidolimab, a high‑affinity humanized immunoglobulin G4 monoclonal antibody, for the treatment of generalized pustular psoriasis.
PHF20 Stabilizes the GAS7-F-Actin Axis to Drive DNA Damage Repair and Chemoresistance in Cutaneous Squamous Cell Carcinoma
[Cell Death & Disease] Researchers observed a positive correlation between PHF20 expression and the malignancy and tumor grade of cutaneous squamous cell carcinoma. Functional studies suggest that PHF20 promotes oncogenic phenotypes, including proliferation, invasion, and epithelial-mesenchymal transition.
NLRP1 Inflammasome Activation in Skin Equivalents Reveals Mechanistic Insights Into the Roles of Keratinocytes in Psoriasis
[Cell Death & Disease] The authors activated the NLRP1 inflammasome in human keratinocytes cultivated in three-dimensional skin equivalents. NLRP1 activation induced histological and molecular features highly reminiscent of psoriasis.
Decoy Antibodies Block Extracellular HSP70, Prevent Self-Signaling, and Inhibit Melanoma Cell Survival
[Cell Reports] Scientists demonstrated for the first time that intravenous injection of melanoma-derived melanosomes into mice elicits protective B cell and antibody responses directed against the extracellular form of heat shock protein 70 (HSP70), a family of key regulators that promote self-signaling and proliferation of melanoma.
Immunotherapy for Early-Stage Cutaneous Squamous Cell Carcinoma
[Journal for Immunotherapy of Cancer] The authors examine current evidence for adjuvant and neoadjuvant immunotherapy in resectable cutaneous squamous cell carcinoma.
microRNA Mir-31-5p Confers Protection to Melanin-Deficient Vitiligo Keratinocytes against UV-B Induced DNA Damage by Activating Autophagy Machinery
[Scientific Reports] Scientists investigated the protective role of microRNA-31-5p, which is elevated in vitiligo lesions, against UV-B-induced DNA damage in keratinocytes.
H3K9me3 Controls Epidermis Morphogenesis by Regulating RNA Pol II Dynamics at Developmental Promoters and Enhancers
[Nature Communications] Investigators showed that H3K9me3 deposition is dynamic during epidermis morphogenesis and essential for lineage diversification.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
