Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

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CytoDyn Announces First Patient Dosed in Phase IIa Study in Collaboration with Weill Cornell Medicine Evaluating Leronlimab in Alzheimer’s Disease

June 12, 2026

[CytoDyn, Inc.] CytoDyn, Inc. announced that the first patient has been dosed in a Phase IIa clinical study evaluating leronlimab in patients with Alzheimer’s disease, in collaboration with Weill Cornell Medicine.

Aberrant Phase Separation of Endothelial MAML1 Causes Congenital Heart Disease by Suppressing Notch Activity

June 12, 2026

[Circulation] Analyses supported Mastermind-like 1 (MAML1) as a candidate gene for congenital heart disease and identify MAML1 liquid-liquid phase separation as a critical biophysical determinant of Notch transcriptional output in endocardial cells.

TNF-α Drives Pancreatic Microcirculatory Dysfunction via CD8 T Cell-Mediated Endothelial Injury in Severe Acute Pancreatitis

June 12, 2026

[Gut] Scientists provided a comprehensive cellular map of human severe acute pancreatitis and uncover a pathogenic immune-endothelial circuit—orchestrated by the TNF-α/UL16-binding protein/NKG2D axis—that drives microcirculatory dysfunction.

Hypoxia Induces Adaptive Lymphangiogenesis via Cd74 and Vegfr3 to Modulate Pulmonary Hypertension

June 12, 2026

[Circulation Research] Using a mouse model to specifically label lymphatic endothelial cells, researchers found that pulmonary lymphatic vessels proliferate and dilate in response to hypoxia. Vegfr3 inhibition using MAZ51 reduced hypoxia induced lymphangiogenesis and was associated with severe pulmonary hypertension.

Reduced BCL2 Level in Astrocytes Contributes to Blood-Brain Barrier Disruption in the Striatum of Offspring Exposed to Maternal Preeclampsia

June 12, 2026

[Molecular Psychiatry] In a rat preeclampsia model, offspring exhibited abnormal behaviors and reduced striatal vascular density, with disrupted blood-brain barrier and swollen astrocytes.

NIH Grant to Fund Innovative Bladder Repair Option for Children

June 12, 2026

[UC Davis Health] A $4 million grant from the National Institutes of Health will help his UC Davis pediatric urologic surgeon Dr, Eric Kurzrock and collaborators test a bioengineered graft infused with ligands (molecules) to treat neuropathic bladders of children with spina bifida or spinal cord injuries.

Remodeling of the Bone Marrow Vasculature Induced by Venetoclax and Azacitidine Damage

June 12, 2026

[Blood] Comparatively high Bcl2 expression in the sinusoidal endothelial cell (SEC) compartment among all stromal subtypes, results in high sensitivity to ven/aza treatment, causing selective depletion of SECs and breakdown in cell-cell communication pathways in the EC network, leading to vascular leakiness in the bone marrow.

Circulating Sphingosine-1-Phosphate Depletion Is Associated with Endothelial Activation and Altered Brain-Endothelial S1P Pathway Expression in Ischemic Stroke

June 12, 2026

[Fluids and Barriers of the CNS] Researchers characterized circulating sphingosine-1-phosphate (S1P) levels together with stroke-associated changes in brain-endothelial S1P pathway expression, markers related to endothelial activation, and blood-brain barrier integrity.

Soluble TREM2 Engages Cell-Surface Nucleolin to Drive Vascular Permeability and Malignant Ascites in Ovarian Cancer

June 1, 2026

[EMBO Molecular Medicine] Using a combination of in vitro, in vivo, and ex vivo models, scientists demonstrated that soluble TREM2 (sTREM2) promotes vascular permeability and drives ascites formation. Mechanistically, sTREM2 binds to nucleolin on endothelial cells and activates the AKT/eNOS signaling pathway, which leads to VE-cadherin phosphorylation and ultimately vascular leakage.

Vascular Mechanical Forces and Vascular Diseases

June 1, 2026

[Journal of Advanced Research] While the significance of mechanical forces in vascular diseases is widely acknowledged, substantial gaps persist in understanding how these forces are sensed and transduced in endothelial cells and vascular smooth muscle cells, as well as their involvement in various vascular diseases.

Four MCG Early-Career Researchers Secure AHA Funding

June 1, 2026

[Jagwire] Four early-career researchers from the Medical College of Georgia at Augusta University have been recently awarded Bridge Career Development Awards from the American Heart Association.

EZH2 Inhibition via GSK-126 Mitigates EndMT and Atherosclerosis in Diabetes: A Translational Epigenetic Approach

June 1, 2026

[Science Advances] Researchers showed that enhancer of zeste homolog 2 (EZH2)-mediated histone H3 at lysine-27 trimethylation is elevated in carotid plaques from patients with diabetes and in the aortic endothelium of diabetic Apoe−/− mice. They identified EZH2 as a driver of endothelial-to-mesenchymal transition in diabetes-associated atherosclerosis.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.