Soluble TREM2 Engages Cell-Surface Nucleolin to Drive Vascular Permeability and Malignant Ascites in Ovarian Cancer

Using a combination of in vitro, in vivo, and ex vivo models, scientists demonstrated that soluble TREM2 (sTREM2) promotes vascular permeability and drives ascites formation. Mechanistically, sTREM2 binds to nucleolin on endothelial cells and activates the AKT/eNOS signaling pathway, which leads to VE-cadherin phosphorylation and ultimately vascular leakage.