Laminar Shear Stress Inhibits Inflammation by Activating Autophagy in Human Aortic Endothelial Cells through HMGB1 Nuclear Translocation

Scientists found that laminar shear stress could inhibit the increased expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, cyclooxygenase-2, and matrix metallopeptidase-9 caused by TNF-α in an autophagy-dependent pathway in human aortic endothelial cells and HUVECs.