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Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
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Cadherin-1-Mediated Communication at the Leader-Follower Boundary Controls Mouse Breast Tumor Organoid Collective Migration
[Cell Reports] Through 3D computational simulations and live video 3D imaging of primary mouse breast tumor organoids in a microfluidic device, researchers investigated the roles of type I cadherins during collective migration.
Gastric Organoid-Based Ectopic and Orthotopic In Vivo CRISPR Screening for Tumor Suppressors in Gastric Cancer
[Gastroenterology] Researchers performed in vivo CRISPR knockout screening for gastric tumor suppressors using gastric murine organoids in a subcutaneous as well as a surgical model of orthotopic tumor growth.
Preconfigured Neuronal Firing Sequences in Human Brain Organoids
[Nature Neuroscience] Scientists demonstrated that structured firing sequences appear in spontaneous activity of human and murine brain organoids, both unguided and forebrain identity-directed, as well as ex vivo neonatal murine cortical slices.
Enhanced Replication of a Contemporary Avian Influenza a H9N2 Virus in Human Respiratory Organoids
[Emerging Microbes & Infections] Investigators underscored the importance of human organoid-based phenotypic monitoring and inter/intrahost genotypic monitoring for assessing the zoonotic risk of avian influenza viruses.
Human Pluripotent Stem Cell-Derived Skin Organoids Enabled Pathophysiological Model of Mycobacterium tuberculosis Infection
[Nature Communications] The authors demonstrated that skin organoids derived from human induced pluripotent stem cells can model cutaneous tuberculosis infected by Mycobacterium tuberculosis.
Development of a Highly Differentiated Rat Brain Organoid Model for Exploring Glioblastoma Invasion Dynamics and Therapy
[Neuro-Oncology] Scientists described the maturation of rat brain organoids (rBOs) into fully differentiated BOs and demonstrated their value as a model for studying glioblastoma-host interactions and their use in testing therapeutic interventions.
Thalamus-Cortex Interactions Drive Cell Type-Specific Cortical Development in Human Pluripotent Stem Cell-Derived Assembloids
[Proceedings of the National Academy of Sciences of the United States of America] Investigators demonstrated thalamus-dependent gene expression, circuit organization, and neural activity during corticogenesis using human thalamocortical assembloids.
Three-Dimensional Magnetic Torque Stimulation Enhances Functional Structural Maturation in Developing Human Cardiac Organoids
[Acta Biomaterialia] Researchers suggested that mechanical force application via a magnetic torque stimulation system can promote both maturation and vascularization of cardiac organoids by activating mechanotransduction pathways.
RAG1 Lentiviral Gene Therapy Restores T-Cell Development of RAG1-SCID Patient Cells in Artificial Thymic Organoids
[Blood Advances] Scientists showed that artificial thymic organoid cultures efficiently support T cell development from healthy donor hematopoietic stem and progenitor cells derived from umbilical cord blood or mobilized peripheral blood, yielding not only αβ but also γδ T cells with a polyclonal T cell receptor repertoire.
Transcriptome Profiling of Tumor-Infiltrating Lymphocyte-Mediated Cytotoxicity against Patient-Derived Lung Cancer Organoids
[Communications Biology] Investigators established a patient-derived organoid and autologous tumor-infiltrating lymphocyte (TIL) co-culture platform to show that expanded TILs mediate potent, specific cytotoxicity against non-small cell lung cancer organoids.
Brain Organoids in Neurodegenerative Disease Modeling: Advances, Applications, and Future Perspectives
[Molecular Neurobiology] The authors delineate the epidemiology and pathobiology of major neurodegenerative diseases, analyze limitations of current animal models, critically evaluate brain organoid generation methodologies, and focus on organoid applications in modeling Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis.
Recent Applications of Lung Organoid and Lung-on-a-Chip Technologies for Evaluating the Toxicity of Fine Particulate Matter
[International Journal of Stem Cells] Researchers summarized the effects of particulate matter 2.5 exposure on human lung and other organoids, as well as the molecular and genetic impacts of such exposure using human organoids.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
