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Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
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Cortical Organoid-Derived Models of the Melanoma Brain Metastatic Niche Enable Prioritization of Cancer-Targeting Drugs
[Cell Reports Methods] To understand and target vulnerabilities of human metastases in a brain niche context, investigators developed reproducible melanoma brain metastasis models for metastasis-integrating drug screening.
Ex Vivo Lung-Organoid Model for Aberrant Basaloid Cell Induction and Activation
[Inflammation and Regeneration] Researchers developed an ex vivo murine lung-organoid model designed to induce and activate aberrant basaloid cells. The organoids were subjected to bleomycin stimulation.
Generation of Human Nucleus Basalis Organoids with Functional Nbm-Cortical Cholinergic Projections in Transplanted Assembloids
[Cell Stem Cell] The authors generated human nucleus basalis of Meynert organoids from hPSCs containing functional cholinergic projection neurons.
Parechovirus-3 Infection Disrupts Immunometabolism and Leads to Glutamate Excitotoxicity in Neural Organoids
[Cellular and Molecular Life Sciences] Through quantitative proteomic analysis of Parechovirus ahumpari 3 (HPeV-3) infected neural organoids, investigators identified unique metabolic changes following HPeV-3 infection that indicate immunometabolic dysregulation.
Mechanotyping of Organoids for Assessing Drug-Induced Injuries
[Advanced Materials] Researchers presented the Centrifugal Mechanical Testing platform, which enables rapid, robust, and label-free mechanotyping of 3D organoids.
A Phenotypic Brain Organoid Atlas and Biobank for Neurodevelopmental Disorders
[Cell Stem Cell] Researchers presented a California Institute of Regenerative Medicine-initiated neurodevelopmental disorder biobank of 352 publicly available genetically diverse patient-derived iPSCs, along with clinical details, brain imaging, and genomic data.
Nonexpansive Biodegradable Matrix Promotes Blood Vessel Organoid Development for Neurovascular Repair and Functional Recovery in Ischemic Stroke
[Nature Biomedical Engineering] Scientists developed a bioinspired, non-expansive biodegradable matrix through covalent–non-covalent assembly of commercially available, clinical-grade natural polymers.
Modeling Antithymocyte Globulin-Induced Microvasculopathy Using Human iPSC-Derived Vascularized Liver Organoids
[Cell Reports Medicine] The authors uncovered a biphasic mechanism of ATG-induced microvasculopathy using a humanized liver organoid platform derived from iPSCs.
Modeling In Vivo Induction of Gastric Insulin-Secreting Cells Using Transplanted Human Stomach Organoids
[Stem Cell Reports] Investigators produced human gastric organoids from hESCs engineered with inducible expression of reprogramming factors.
Advances in Sweat Gland Organoids: Construction, Molecular Mechanisms, and Challenges
[Stem Cell Research & Therapy] The authors summarize the molecular regulatory mechanisms underlying sweat gland development and focus on the latest progress in sweat gland organoid construction.
Exploration of Biomaterial and Stem Cell-Based Strategies for Promoting Neuronal Regeneration and Creating Engineered 3D In Vitro Disease Models
[Journal of Translational Medicine] Investigators focus on stem cell-based neuronal repair by using biomaterials. They discuss neural tissue damage and the associated mechanisms in neuronal repair.
Human Neural Organoid Research Needs Better Regulation
[The Scientist] In the past decade, human neural organoid research has been moving at a “break-neck pace,” but it lacks the legal and ethical guidelines that should accompany a field that is “peculiarly ethically sensitive.”
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
