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Pancreatic Cell News
Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis
[Cancer Research] Using patient-derived organoid models, single-cell RNA sequencing, and multiplex immunofluorescence staining of samples from patients with PDAC, in vivo TGFβ1 conditional knockout mouse models, and 3D in vitro models, scientists discovered that the formation of intratumoral necrotic foci in pancreatic cancer is closely associated with liver metastatic events.
An Allele-Agnostic Mutant-KRAS Inhibitor Suppresses Tumor Maintenance Signals and Reprograms Tumor Immunity in Pancreatic Cancer
[Science Translational Medicine] Researchers comprehensively evaluated the preclinical efficacy of BI-2493, a first-in-class allele-agnostic mutant-KRAS inhibitor, in PDAC.
PIM1 Protects Pancreatic Ductal Cancer Cells from Glucose Deprivation-Induced Oxidative Stress via OXR1 Phosphorylation
[Biochimica Et Biophysica Acta-Molecular Basis of Disease] Investigators found that PIM1, a serine/threonine kinase, is upregulated in PDAC tumors and serves as a poor prognostic indicator.
Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Pro-Tumorigenic T Cell Polarization
[Cancer Discovery] The authors showed that aryl hydrocarbon receptor ligands found in cigarette smoke, like the carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin, promote pancreatic dysplasia and PDAC progression in a mouse model of this disease.
PI5P4Kα Promotes Glucose and Iron Acquisition to Support Metabolic Fitness in Pancreatic Cancer
[Cell Reports] Scientists identified phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) α as a critical dependency to support the unique metabolic demands of PDAC cells through its key role in the acquisition of essential metabolic substrates, including glucose and iron.
A Vascular-Associated Fibroblastic Cell Controls Pancreatic Islet Immunity
[Cell Reports] In non-diabetic mouse and human islets, two cells were detected outside of the islet boundaries near the efferent post-capillary venules: one related to the vasculature and a fibroblast referred to as a vascular-associated fibroblast.
Mitochondrial Quality Control in Diabetes Mellitus and Complications: Molecular Mechanisms and Therapeutic Strategies
[Cell Death & Disease] The authors highlight newly discovered processes involving mitochondrial-derived vesicles, licensed mitophagy, and mitocytosis that broaden the regulatory landscape of mitochondrial quality control.
Wayne State Research Aims to Improve Quality of Life for People with Type 1 Diabetes
[Wayne State University] Supported by a $300,000 grant from Breakthrough T1D International, Dr. Zhiqiang Cao is developing a next-generation ultra-rapid insulin designed to dramatically accelerate insulin action and remove the need for user input at mealtime.
PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer
[Cancer Research] Investigators showed that nutrient starvation and microenvironmental signals commonly present in PDAC tumors activate PPARδ to rewire cellular metabolism and promote invasive and metastatic properties both in vitro and in vivo.
Siraitia grosvenorii Extract Improves Insulin Tolerance and Pancreatic Islet Function in Aging and HFD-Induced Diabetic Mice
[Food & Function] M3 extract, containing 68.5% siamenoside I, was administered by gavage in aging and high-fat diet (HFD)-fed diabetic C57BL/6J mice.
Beta Cell Dysfunction Occurs Independently of Insulitis in Type 1 Diabetes Pathogenesis
[Cell Reports] Researchers investigated the hypothesis that the remaining beta cells in T1D are dysfunctional, using live pancreas slices from organ donors recently diagnosed with T1D.
Mitochondrial-Encoded Peptide MOTS-C Prevents Pancreatic Islet Cell Senescence to Delay Diabetes
[Experimental & Molecular Medicine] Scientists showed that mitochondrial ORF of the 12S rRNA type-c (MOTS-c) levels decrease with aging and senescence in pancreatic islet cells. Treating aged C57BL/6 mouse pancreatic islets with MOTS-c reduced pancreatic islet senescence by modulating nuclear gene expression and metabolites involved in β-cell senescence.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
