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Prostate Cell News
Prostate Cell News is an online resource summarizing the latest prostate cell research.
Divergent FOXA1 Mutations Drive Prostate Tumorigenesis and Therapy-Resistant Cellular Plasticity
[Science] Investigators established FOXA1 as a multifaceted oncogene, with distinct mutational classes divergently evolving to drive prostate tumorigenesis or therapy-resistant progression.
Innate Immunity and the NF-κB Pathway Control Prostate Stem Cell Plasticity, Reprogramming, and Tumor Initiation
[Nature Cancer] Researchers showed that Pten deletion in basal cells led to distinct cell fate reprogramming and tumor initiation in a regionalized manner.
Isoform-Specific Function of NSD3 in DNA Replication Stress Confers Resistance to PARP Inhibitors in Prostate Cancer
[Molecular Cell] Scientists demonstrated that dysregulated ubiquitination and turnover by the cullin 3ZBTB2 E3 ligase complex induce the upregulation of the short isoform of nuclear-receptor-binding SET domain protein 3, which confers PARPi resistance in prostate cancer cells and patient-derivedmetastatic castration-resistant prostate cancer samples.
PruEV-AI: A Simple Approach Combines Urinary Extracellular Vesicle Isolation With AI-Assisted Analysis for Prostate Cancer Diagnosis
[Small Methods] Scientists introduced PruEV-AI, an integrated diagnostic system that combines rapid urinary extracellular vesicles isolation with AI-based biomarker analysis.
Spatial Metabolomics Informs the Use of Clinical Imaging for Improved Detection of Cribriform Prostate Cancer
[Proceedings of the National Academy of Sciences of the United States of America] Investigators supported the feasibility of using clinical metabolic imaging techniques as adjunctive tools for improving cribriform prostate cancer detection in clinical practice, with prospective studies in larger cohorts warranted to obtain definitive results.
Fine Structural Design of 3βHSD1 Inhibitors for Prostate Cancer Therapy
[Proceedings of the National Academy of Sciences of the United States of America] Scientists demonstrated the feasibility of using predicted structural models for optimizing lead compounds, and HEAL-116 provides a promising avenue for the clinical validation of 3βHSD1 inhibitors in prostate cancer therapy.
The Role of Estrogen Receptor β in Maintaining Basal Cells and Modulating the Immune Environment in the Prostate
[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that ERβ was critical for the maintenance of basal cells in the prostate and controlling prostatic inflammation.
Identification of MUC1-C Dependence in Drug-Resistant Advanced Prostate Cancer Uncovers a Target for Antibody-Drug Conjugate Therapy
[JCI Insight] Researchers uncovered a common MUC1-C-dependent pathway in treatment-resistant castration resistant prostate cancer/neuroendocrine prostate cancer progression and identified MUC1-C as a target for their treatment with a M1C antibody-drug conjugate.
Diagnostic Value of CD138 and GATA3 in Benign Prostatic Hyperplasia and Prostate Cancer
[Discover Oncology] Scientists evaluated the diagnostic utility of GATA3 and CD138 as basal compartment markers in differentiating benign prostatic hyperplasia from prostate cancer.
The Role and Therapeutic Value of NUSAP1 in Human Cancers
[Journal of Translational Medicine] The authors discuss the roles and mechanisms of nucleolar and spindle-associated protein 1 (NUSAP1) in human cancers.
AB Science: Masitinib receives FDA and EMA authorization for confirmatory phase 3 trial in metastatic castrate-resistant prostate cancer
[AB Science] AB Science announced that a confirmatory Phase III trial of masitinib in metastatic castrate resistant prostate cancer has been authorized by the FDA and EMA, with a biomarker that targets patients with less advanced metastatic disease.
Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells.
[Journal of the American Chemical Society] Scientists utilized a cysteine-reactive covalent ligand library in a cellular screen to identify degraders of the androgen receptor (AR) and AR-V7 in androgen-independent prostate cancer cells.
Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.
