Ezra Receives FDA Clearance For Prostate Cancer Artificial Intelligence

Ezra announced that it has received FDA 510(k) premarket authorization for its Artificial Intelligence (AI), designed to decrease the cost of MRI-based cancer screening, assisting radiologists in their analysis of prostate MRI scans. It is the first Prostate AI to ever be cleared by the FDA.
[Ezra (PR Newswire, Inc.)]
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Post-Translational Modification of KRAS: Potential Targets for Cancer Therapy

The authors summarize the regulatory mode of post-translational modifications on KRAS. They also highlight the recent studies targeting these modifications having exhibited potent anti-tumor activities, including in prostate cancer.
[Acta Pharmacologica Sinica]
Wang, W., Yuan, T., Qian, M., Yan, F., Yang, L., He, Q., Yang, B., Lu, J., & Zhu, H. (2020). Post-translational modification of KRAS: potential targets for cancer therapy. Acta Pharmacologica Sinica, 1–11. https://doi.org/10.1038/s41401-020-00542-y Cite
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The Alpha-1,2 Fucosylated Tubule System of DU145 Prostate Cancer Cells Is Derived from a Partially Fragmented Golgi Complex and Its Formation Is Actin-Dependent

The authors present evidence that in the prostate cancer cell line DU145, the tubules arise in actively growing cells from vesicles in the medial and trans elements of a partially fragmented Golgi complex, while in not actively growing cells the tubules become completely independent from the Golgi complex.
[Experimental Cell Research]
Nolfi, D., Capone, A., Rosati, F., & Della Giovampaola, C. (2020). The alpha-1,2 fucosylated tubule system of DU145 prostate cancer cells is derived from a partially fragmented Golgi complex and its formation is actin-dependent. Experimental Cell Research, 396(2), 112324. https://doi.org/10.1016/j.yexcr.2020.112324 Cite
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Delineating Role of NF-κB and Interacting Cytokines during Prostate Cancer-Induced Osteoclastogenesis

Researchers investigated the role and mechanisms by which prostate cancer cells induce osteoclastogenesis using cultured monocytic osteoclast precursors.
[Journal of Cellular Biochemistry]
Jadli, M., Thakur, K., Aggarwal, N., Chhokar, A., Bibban, R., Singh, T., Bhat, A., & Bharti, A. C. (n.d.). Delineating role of NF-κB and interacting cytokines during prostate cancer-induced osteoclastogenesis. Journal of Cellular Biochemistry, n/a(n/a). https://doi.org/10.1002/jcb.29856 Cite
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Estimation of Mandarin Peel Oil Induced Cytotoxicity and Genotoxicity in Human Normal Fibroblast and Cancerous Prostate Cell Lines

Scientists studied the cytotoxicity and genotoxicity of Mandarin peel oil on Human normal Fibroblast (HFB4) and PC3 prostate cell lines.
[Toxicology Mechanisms and Methods]
Hussien, N. A., & Mohamed, H. R. H. (2020). Estimation of Mandarin Peel Oil induced Cytotoxicity and genotoxicity in Human Normal Fibroblast and Cancerous Prostate Cell Lines. Toxicology Mechanisms and Methods, 0(ja), 1–20. https://doi.org/10.1080/15376516.2020.1836103 Cite
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DLX6-AS1 Accelerates Cell Proliferation through Regulating miR-497-5p/SNCG Pathway in Prostate Cancer

Scientists observed that DLX6‐AS1 was significantly upregulated in prostate cancer (PCa) tissues and cells. Knockdown of DLX6‐AS1 inhibited PCa progression by suppressing cell proliferation and accelerating cell apoptosis.
[Environmental Toxicology]
Zhu, X., Ma, X., Zhao, S., & Cao, Z. (n.d.). DLX6-AS1 accelerates cell proliferation through regulating miR-497-5p/SNCG pathway in prostate cancer. Environmental Toxicology, n/a(n/a). https://doi.org/10.1002/tox.23036 Cite
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ROS-Mediated Genotoxic Stress Is Involved in NaAsO2-Induced Cell Cycle Arrest, Stemness Enhancement and Chemoresistance of Prostate Cancer Cells in a p53-Independent Manner

The authors suggest that ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner.
[Ecotoxicology and Environmental Safety]
Zhang, Z.-H., Hong, Q., Zhang, Z.-C., Xing, W.-Y., Xu, S., Tian, Q.-X., Ye, Q.-L., Wang, H., Yu, D.-X., Xie, D.-D., & Xu, D.-X. (2021). ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner. Ecotoxicology and Environmental Safety, 208, 111436. https://doi.org/10.1016/j.ecoenv.2020.111436 Cite
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TAp63 and ΔNp63 (p40) in Prostate Adenocarcinomas: ΔNp63 Associates with a Basal-Like Cancer Stem Cell Population but Not with Metastasis

Investigators studied metastatic deposits of prostate cancers with isoform-specific ΔNp63 and TAp63 antibodies. They identified p63-positive cells in only 3 of 42 metastatic prostate tumors, including 2/38 “usual-type” adenocarcinomas. ΔNp63 and TAp63 isoforms were present in the nuclei of < 1% of tumor cells in these metastases.
[Virchows Archiv]
Galoczova, M., Nenutil, R., Pokorna, Z., Vojtesek, B., & Coates, P. J. (2020). TAp63 and ΔNp63 (p40) in prostate adenocarcinomas: ΔNp63 associates with a basal-like cancer stem cell population but not with metastasis. Virchows Archiv. https://doi.org/10.1007/s00428-020-02944-z Cite
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Combination of rAd-p53 In Situ Gene Therapy and Anti-PD-1 Antibody Immunotherapy Induced Anti-Tumor Activity in Mouse Syngeneic Urogenital Cancer Models

Researchers undertook a novel combination therapy using rAd-p53 in situ gene therapy and immunotherapy with immune checkpoint inhibitor anti-PD-1 antibody for urogenital cancers. Three mouse syngeneic tumor cell lines, TRAMP-C2 (prostate), MBT-2 (bladder) and Renca (kidney) were used.
[Scientific Reports]
Kunimura, N., Kitagawa, K., Sako, R., Narikiyo, K., Tominaga, S., Bautista, D. S., Xu, W., Fujisawa, M., & Shirakawa, T. (2020). Combination of rAd-p53 in situ gene therapy and anti-PD-1 antibody immunotherapy induced anti-tumor activity in mouse syngeneic urogenital cancer models. Scientific Reports, 10(1), 17464. https://doi.org/10.1038/s41598-020-74660-2 Cite
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Targetable Gene Fusions and Aberrations in Genitourinary Oncology

Th authors summarize current knowledge of the main gene fusions in genitourinary malignancies, discuss their growing importance in the understanding of the biology of tumours, and highlight their potential use as targets for precision medicine approaches.
[Nature Reviews Urology]
Pederzoli, F., Bandini, M., Marandino, L., Ali, S. M., Madison, R., Chung, J., Ross, J. S., & Necchi, A. (2020). Targetable gene fusions and aberrations in genitourinary oncology. Nature Reviews Urology, 1–13. https://doi.org/10.1038/s41585-020-00379-4 Cite
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CLS and University Hospital Magdeburg Launch Clinical Trial Regarding Focal Laser Ablation Treatment of Localized Prostate Cancer

Clinical Laserthermia Systems and Otto-von-Guericke-University Magdeburg Medical faculty are entering into an agreement regarding an Investigator Initiated Trial targeting MRI-Ultrasound fusion guided focal laser ablation treatment of prostate cancer.
[Clinical Laserthermia Systems AB (publ)]
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