Lixte Biotechnology Announces Collaboration with Netherlands Cancer Institute (Amsterdam) and Oncode Institute (Utrecht) to Identify the Most Promising Drug Combinations for its Lead Clinical Compound, LB-100, for Cancer Treatment

Lixte Biotechnology Holdings, Inc. announced entry into a collaboration with the Netherlands Cancer Institute, Amsterdam, and Oncode Institute, Utrecht to identify the most promising drugs to be combined with LB-100, and potentially LB-100 analogues, to be used to treat a range of cancers, as well as to identify the specific molecular mechanisms underlying the identified combinations.
[Lixte Biotechnology Holdings, Inc.]
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Single-Cell Analysis Reveals Androgen Receptor Regulates the ER-to-Golgi Trafficking Pathway with CREB3L2 to Drive Prostate Cancer Progression

Scientists used single-cell transcriptome analysis to reconstruct the transcriptional network of androgen receptor (AR) in prostate cancer. They showed that AR directly regulated a set of signature genes in the ER-to-Golgi protein vesicle-mediated transport pathway.
[Oncogene]
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Computational Modeling Identifies Multitargeted Kinase Inhibitors as Effective Therapies for Metastatic, Castration-Resistant Prostate Cancer

Researchers applied a systems-based modeling approach called kinome regularization to identify multitargeted kinase inhibitors that abrogate castration-resistant prostate cancer growth.
[Proceedings of the National Academy of Sciences of the United States of America]
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GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer

The authors showed that GLI3, a key SHH pathway effector, was transcriptionally upregulated during androgen deprivation and posttranslationally stabilized in prostate cancer cells by mutation of speckle-type POZ protein.
[Molecular Cancer Research]
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Synthesis of 3′- O-Alkyl Homologues and a Biotin Probe of Isorhamnetin and Evaluation of Cytotoxic Efficacy on Cancer Cells

Investigators synthesized 3′- O -substituted quercetin as isorhamnetin analogues and evaluated the growth inhibitory activity of these derivatives on breast, colon and prostate cancer cell lines.
[Chemistry & Biodiversity]
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Metformin and Sodium Dichloroacetate Effects on Proliferation, Apoptosis, and Metabolic Activity Tested Alone and in Combination in a Canine Prostate and a Bladder Cancer Cell Line

Researchers evaluated the independent and synergistic effect of metformin and sodium dichloroacetate on the metabolic activity, cell proliferation, and apoptosis of a canine prostate adenocarcinoma and a transitional cell carcinoma cell line in comparison to a primary canine fibroblast culture.
[PLOS ONE]
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Panobinostat Reverses HepaCAM Gene Expression and Suppresses Proliferation by Increasing Histone Acetylation in Prostate Cancer

Scientists investigated the effect of panobinostat, the broad-spectrum histone deacetylases inhibitor, on prostate cancer LNCaP and DU145 cell growth, and observed re-expression of hepatocyte cell adhesion molecule when treated with panobinostat.
[Gene]
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Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer

Scientists analyzed cell lines, patient-derived xenograft models and human clinical samples to show the existence of two distinct NEPC subtypes based on the expression of the neuronal transcription factors ASCL1 and NEUROD1.
[Nature Communications]
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Aptamer-Conjugated Mesoporous Polydopamine for Docetaxel Targeted Delivery and Synergistic Photothermal Therapy of Prostate Cancer

Researchers constructed multifunctional nanoparticles, namely AS1411@MPDA-DTX for targeted and synergistic chemotherapy/photothermal therapy of prostate cancer.
[Cell Proliferation]
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Autophagy Provides a Conceptual Therapeutic Framework for Bone Metastasis from Prostate Cancer

The authors sum up the recent studies on the mechanism of bone metastasis involving key regulatory factors such as macrophages and AKT and further discusses as to how regulating autophagy is crucial in relieving prostate cancer bone metastasis.
[Cell Death & Disease]
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Building Better Lab Models of Human Tumors

Prostate cancer researcher Dr. John Lee garnered a National Institutes of Health New Innovator Award to fund his breakthrough approach that promises to help make scientific tumor models better capture the complex biology of tumors that arise naturally.
[Fred Hutchinson Cancer Research Center]
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