Loss and Revival of Androgen Receptor Signaling in Advanced Prostate Cancer

The authors review the molecular mechanisms that enable cancer cells to switch from an androgen receptor (AR)-positive to an AR-negative disease and efforts to prevent/revert this process and thereby maintain/restore AR-dependence.
[Oncogene]
Formaggio, N., Rubin, M. A., & Theurillat, J.-P. (2021). Loss and revival of androgen receptor signaling in advanced prostate cancer. Oncogene, 1–12. https://doi.org/10.1038/s41388-020-01598-0 Cite
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MAOA Promotes Prostate Cancer Cell Perineural Invasion through SEMA3C/PlexinA2/NRP1-cMET Signaling

Investigators report that monoamine oxidase A (MAOA) is a clinically and functionally important mediator of perineural invasion (PNI) in prostate cancer (PV). MAOA promotes PNI of PC cells in vitro and tumor innervation in an orthotopic xenograft model.
[Oncogene]
Yin, L., Li, J., Wang, J., Pu, T., Wei, J., Li, Q., & Wu, B. J. (2021). MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1–cMET signaling. Oncogene, 1–13. https://doi.org/10.1038/s41388-020-01615-2 Cite
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Single-Cell Analysis Reveals Transcriptomic Remodellings in Distinct Cell Types that Contribute to Human Prostate Cancer Progression

Scientists showed that activated endothelial cells are enriched in castration-resistant prostate cancer and promote cancer cell invasion. Researchers created a user-friendly web interface for users to explore the sequenced data.
[Nature Cell Biology]
Chen, S., Zhu, G., Yang, Y., Wang, F., Xiao, Y.-T., Zhang, N., Bian, X., Zhu, Y., Yu, Y., Liu, F., Dong, K., Mariscal, J., Liu, Y., Soares, F., Loo Yau, H., Zhang, B., Chen, W., Wang, C., Chen, D., … Ren, S. (2021). Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression. Nature Cell Biology, 23(1), 87–98. https://doi.org/10.1038/s41556-020-00613-6 Cite
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LOX-1 and Cancer: An Indissoluble Liaison

The authors outline the role of LOX-1 in tumor spreading and metastasis, evidencing its function in VEGF induction, HIF-1alpha activation, and MMP-9/MMP-2 expression, pushing up the neoangiogenic and the epithelial-mesenchymal transition process in glioblastoma, osteosarcoma, prostate, colon, breast, lung, and pancreatic tumors.
[Cancer Gene Therapy]
Murdocca, M., De Masi, C., Pucci, S., Mango, R., Novelli, G., Di Natale, C., & Sangiuolo, F. (2021). LOX-1 and cancer: an indissoluble liaison. Cancer Gene Therapy, 1–11. https://doi.org/10.1038/s41417-020-00279-0 Cite
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Post-Transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer

Scientists showed that microRNA-194 (miR-194) is a regulator of epithelial-neuroendocrine (NE) transdifferentiation. In clinical prostate cancer (PC) samples, miR-194 expression and activity were elevated in NEPC and inversely correlated with androgen receptor signaling.
[Cell Reports]
Fernandes, R. C., Toubia, J., Townley, S., Hanson, A. R., Dredge, B. K., Pillman, K. A., Bert, A. G., Winter, J. M., Iggo, R., Das, R., Obinata, D., Sandhu, S., Risbridger, G. P., Taylor, R. A., Lawrence, M. G., Butler, L. M., Zoubeidi, A., Gregory, P. A., Tilley, W. D., … Selth, L. A. (2021). Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer. Cell Reports, 34(1). https://doi.org/10.1016/j.celrep.2020.108585 Cite
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WLS-Wnt Signaling Promotes Neuroendocrine Prostate Cancer

Scientists report that the Wnt secretion mediator Wntless (WLS) is a major driver of neuroendocrine prostate cancer and aggressive tumor growth <>in vitro and in vivo.
[iScience]
Bland, T., Wang, J., Yin, L., Pu, T., Li, J., Gao, J., Lin, T.-P., Gao, A. C., & Wu, B. J. (2021). WLS-Wnt signaling promotes neuroendocrine prostate cancer. IScience, 24(1). https://doi.org/10.1016/j.isci.2020.101970 Cite
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Vitamin D Sufficiency Enhances Differentiation of Patient-Derived Prostate Epithelial Organoids

To determine vitamin D regulation of prostatic epithelial differentiation, patient-derived benign prostate epithelial organoids were grown in vitamin D deficient or sufficient conditions.
[iScience]
McCray, T., Pacheco, J., Loitz, C., Garcia, J., Baumann, B., Schlicht, M. J., Valyi-Nagy, K., Abern, M. R., & Nonn, L. (2020). Vitamin D Sufficiency Enhances Differentiation of Patient-Derived Prostate Epithelial Organoids. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101974 Cite
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Nerve Growth Factor Interacts with CHRM4 and Promotes Neuroendocrine Differentiation of Prostate Cancer and Castration Resistance

The authors showed that an androgen-deprivation therapy-stimulated transcription factor, ZBTB46, upregulated NGF via ZBTB46 mediated-transcriptional activation of nerve growth factor.
[Communications Biology]
Chen, W.-Y., Wen, Y.-C., Lin, S.-R., Yeh, H.-L., Jiang, K.-C., Chen, W.-H., Lin, Y.-S., Zhang, Q., Liew, P.-L., Hsiao, M., Huang, J., & Liu, Y.-N. (2021). Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance. Communications Biology, 4(1), 1–14. https://doi.org/10.1038/s42003-020-01549-1 Cite
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Identification of PIM1 Substrates Reveals a Role for NDRG1 Phosphorylation in Prostate Cancer Cellular Migration and Invasion

Investigators performed a direct, unbiased chemical genetic screen to identify pro-viral integration site for Moloney murine leukemia virus-1 (PIM1) substrates in prostate cancer cells.
[Communications Biology]
Ledet, R. J., Ruff, S. E., Wang, Y., Nayak, S., Schneider, J. A., Ueberheide, B., Logan, S. K., & Garabedian, M. J. (2021). Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion. Communications Biology, 4(1), 1–12. https://doi.org/10.1038/s42003-020-01528-6 Cite
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Reciprocal Interactions between Tumour Cell Populations Enhance Growth and Reduce Radiation Sensitivity in Prostate Cancer

Researchers evaluated whether interactions between heterogenous populations could impact growth and response to radiotherapy in prostate cancer.
[Communications Biology]
Paczkowski, M., Kretzschmar, W. W., Markelc, B., Liu, S. K., Kunz-Schughart, L. A., Harris, A. L., Partridge, M., Byrne, H. M., & Kannan, P. (2021). Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer. Communications Biology, 4(1), 1–13. https://doi.org/10.1038/s42003-020-01529-5 Cite
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Myovant Sciences and Pfizer Announce Collaboration to Develop and Commercialize Relugolix in Oncology and Women’s Health

Myovant Sciences and Pfizer Inc. have announced a collaboration to develop and commercialize relugolix – a once-daily, oral gonadotropin-releasing hormone receptor antagonist – in oncology and women’s health in the U.S. and Canada. Pfizer will also receive an exclusive option to commercialize relugolix in oncology outside the U.S. and Canada, excluding certain Asian countries.
[Myovant Sciences GmbH.]
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