Role of Noncoding RNA in Drug Resistance of Prostate Cancer

Scientists summarize the important roles of these three classes of noncoding RNA in drug resistance and the potential therapeutic applications in prostate cancer.
[Cell Death & Disease]
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Mapping Genetic Variability in Mature miRNAs and miRNA Binding Sites in Prostate Cancer

Using genome-wide target capture of miRNAs and miRNA-binding sites followed by deep sequencing in prostate cancer cell lines, researchers identified prostate cancer-specific single nucleotide variants in mature miRNAs and their target binding sites.
[Journal of Human Genetics]
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Temporal Evolution of Cellular Heterogeneity during the Progression to Advanced AR-Negative Prostate Cancer

Single-cell-based approaches revealed striking temporal changes to the transcriptome and chromatin accessibility which have identified the emergence of distinct cell populations, marked by differential expression of Ascl1 and Pou2f3, during the transition to neuroendocrine prostate cancer.
[Nature Communications]
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HJURP Promotes Proliferation in Prostate Cancer Cells through Increasing CDKN1A Degradation via the GSK3β/JNK Signaling Pathway

Investigators found a total of 137 genes were ectopically expressed in eight cancer types, of which Holliday junction recognition protein (HJURP) was significantly upregulated in prostate cancer.
[Cell Death & Disease]
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Tissue Microarray Profiling and Integrative Proteomics Indicate the Modulatory Potential of Maytenus royleanus in Inhibition of Overexpressed TPD52 in Prostate Cancers

Scientists explored the mechanism of action of Maytenus royleanus (MEM) in prostate cancer (PCa) by employing an in vitro global proteome approach to get useful information of various signaling pathways and effected genes to define the mechanism of MEM action in Pca.
[Scientific Reports]
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Dynamic Patterns of DNA Methylation in the Normal Prostate Epithelial Differentiation Program Are Targets of Aberrant Methylation in Prostate Cancer

The authors utilized the established non-malignant HPr1-AR prostate epithelial cell model that upon androgen exposure committed to a luminal cell differentiation trajectory from that of a basal-like state.
[Scientific Reports]
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The Heavy Chain of 4F2 Antigen Promote Prostate Cancer Progression via SKP-2

Treatment of C4-2 cells with the 4F2 cell-surface antigen heavy chain was found to suppress cellular growth, migratory and invasive abilities, with this effect occurring through the cell cycle, with a significant decrease in S phase and a significant increase in G0/G1 phase, suggesting cell cycle arrest.
[Scientific Reports]
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A New Role of GRP75-USP1-SIX1 Protein Complex in Driving Prostate Cancer Progression and Castration Resistance

Scientists showed that the molecular chaperone GRP75 is a key player in prostate cancer cells by maintaining the protein stability of SIX1, a transcription factor for embryonic development.
[Oncogene]
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FKBP51 and FKBP52 Regulate Androgen Receptor Dimerization and Proliferation in Prostate Cancer Cells

Researchers found that depletion of either FKBP51 or FKBP52 reduced androgen receptor(AR) dimer formation, chromatin binding and phosphorylation, suggesting defective AR signaling.
[Molecular Oncology]
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Preparation of Catechin Nanoemulsion from Oolong Tea Leaf Waste and Its Inhibition of Prostate Cancer Cells DU-145 and Tumors in Mice

Anti-cancer activity of catechin nanoemulsions prepared from Oolong tea leaf waste was studied on prostate cancer cells DU-145 and DU-145-induced tumors in mice.
[Molecules]
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LncRNA PCA3 Promotes Antimony-Induced Lipid Metabolic Disorder in Prostate Cancer by Targeting MIR-132-3 P/SREBP1 Signaling

Scientists found that chronic exposure to antimony promoted cell growth and lipid metabolic disequilibrium in prostate cancer.
[Toxicology Letters]
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