Optimizing the Diagnosis and Management of Ductal Prostate Cancer

Although current understanding of the biology of ductal adenocarcinoma is limited, genomic analyses have provided insights into the pathology behind its aggressive behavior and potential future therapeutic targets.
[Nature Reviews Urology]
Optimizing the diagnosis and management of ductal prostate cancer | Nature Reviews Urology. (n.d.). Retrieved April 8, 2021, from https://www.nature.com/articles/s41585-021-00447-3 Cite
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Reprogramming of the FOXA1 Cistrome in Treatment-Emergent Neuroendocrine Prostate Cancer

Researchers established the importance of FOXA1 in NEPC and provide a principled approach to identifying cancer dependencies through epigenomic profiling.
[Nature Communications]
Baca, S. C., Takeda, D. Y., Seo, J.-H., Hwang, J., Ku, S. Y., Arafeh, R., Arnoff, T., Agarwal, S., Bell, C., O’Connor, E., Qiu, X., Alaiwi, S. A., Corona, R. I., Fonseca, M. A. S., Giambartolomei, C., Cejas, P., Lim, K., He, M., Sheahan, A., … Freedman, M. L. (2021). Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer. Nature Communications, 12(1), 1979. https://doi.org/10.1038/s41467-021-22139-7 Cite
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A Glutaminase Isoform Switch Drives Therapeutic Resistance and Disease Progression of Prostate Cancer

The authors report a glutaminase isoform switch mechanism that mediated the initial therapeutic effect but eventual failure of hormonal therapy of prostate cancer.
[Proceedings of the National Academy of Sciences of the United States of America]
Xu, L., Yin, Y., Li, Y., Chen, X., Chang, Y., Zhang, H., Liu, J., Beasley, J., McCaw, P., Zhang, H., Young, S., Groth, J., Wang, Q., Locasale, J. W., Gao, X., Tang, D. G., Dong, X., He, Y., George, D., … Huang, J. (2021). A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer. Proceedings of the National Academy of Sciences, 118(13). https://doi.org/10.1073/pnas.2012748118 Cite
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Myovant Sciences Announces Recipients of “Forward for Health Equity” Grants to Improve Healthcare Access in Prostate Cancer and Uterine Fibroids

Myovant Sciences announced the four recipients of its Forward for Health Equity grants. The grant program provides funding to nonprofit healthcare organizations with innovative projects focused on improving healthcare access, with an initial focus on reducing racial disparities in prostate cancer and uterine fibroids in the US.
[Myovant Sciences]
Press Release
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Bio-Techne’s Exosome Diagnostics Laboratory Announces CE-IVD Certification For ExoDx Prostate Test

Bio-Techne Corporation announced that Exosome Diagnostics, a Bio-Techne brand, has completed its clinical validation of an in vitro diagnostic (IVD) version of the ExoDx Prostate test kit enabling self-certification as CE-IVD.
[Bio-Techne Corporation]
Press Release
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Stomatin-Mediated Inhibition of the Akt Signaling Axis Suppresses Tumor Growth

Investigators found that stomatin expression was markedly upregulated by the interaction between prostate cancer cells and stromal cells.
[Cancer Research]
Rahman, N. I. A., Sato, A., Tsevelnorov, K., Shimizu, A., Komeno, M., Amin, M. K. B. A., Molla, M. R., Soh, J. E. C., Nguyen, L. K. C., Wada, A., Kawauchi, A., & Ogita, H. (2021). Stomatin-mediated inhibition of the Akt signaling axis suppresses tumor growth. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2331 Cite
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CASC11 Promotes Aggressiveness of Prostate Cancer Cells through miR-145/IGF1R Axis

The authors explored the potential functions of CASC11 in association with miR-145 and IGF1R during the malignant progression of prostate cancer cells.
[Prostate Cancer and Prostatic Diseases]
Capik, O., Sanli, F., Kurt, A., Ceylan, O., Suer, I., Kaya, M., Ittmann, M., & Karatas, O. F. (2021). CASC11 promotes aggressiveness of prostate cancer cells through miR-145/IGF1R axis. Prostate Cancer and Prostatic Diseases, 1–12. https://doi.org/10.1038/s41391-021-00353-0 Cite
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Distinct DNA Methylation Patterns Associated with Treatment Resistance in Metastatic Castration Resistant Prostate Cancer

Using an established xenograft model of castration-resistant prostate cancer (CRPC), genome-wide methylation analysis was performed on cell lines representing various stages of PC progression. Investigators confirmed extensive methylation changes with the development of CRPC and treatment-induced neuroendocrine disease using this model.
[Scientific Reports]
Peter, M. R., Bilenky, M., Davies, A., Isserlin, R., Bader, G. D., Fleshner, N. E., Hirst, M., Zoubeidi, A., & Bapat, B. (2021). Distinct DNA methylation patterns associated with treatment resistance in metastatic castration resistant prostate cancer. Scientific Reports, 11(1), 6630. https://doi.org/10.1038/s41598-021-85812-3 Cite
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PCA3 Controls Chromatin Organization and p53 Signal Activation by Regulating LAP2α-Lamin a Complexes

Researchers report that lncRNA Prostate cancer antigen 3 (PCA3) played a role in prostate cancer progression that was mediated by nucleoplasmic lamins.
[Cancer Gene Therapy]
Ito, S., Ueda, T., Yokoyama, A., Fujihara, A., Hongo, F., & Ukimura, O. (2021). PCA3 controls chromatin organization and p53 signal activation by regulating LAP2α-lamin A complexes. Cancer Gene Therapy, 1–11. https://doi.org/10.1038/s41417-021-00314-8 Cite
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Kinesin Family Member 18B Regulates the Proliferation and Invasion of Human Prostate Cancer Cells

In vitro, kinesin family member 18B (KIF18B) knockdown in prostate cancer cell lines promoted cell proliferation, migration, and invasion, and inhibited cell apoptosis, while KIF18B overexpression had the opposite effects.
[Cell Death & Disease]
Wu, Y.-P., Ke, Z.-B., Zheng, W.-C., Chen, Y.-H., Zhu, J.-M., Lin, F., Li, X.-D., Chen, S.-H., Cai, H., Zheng, Q.-S., Wei, Y., Xue, X.-Y., & Xu, N. (2021). Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells. Cell Death & Disease, 12(4), 1–15. https://doi.org/10.1038/s41419-021-03582-2 Cite
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FGF21 Facilitates Autophagy in Prostate Cancer Cells by Inhibiting the PI3K–Akt–mTOR Signaling Pathway

Scientists investigated the action of Fibroblast growth factor 21 (FGF21) in the development of prostate cancer (PCa). They found that FGF21 expression was markedly downregulated in PCa tissues and cell lines.
[Cell Death & Disease]
Dai, H., Hu, W., Zhang, L., Jiang, F., Mao, X., Yang, G., & Li, L. (2021). FGF21 facilitates autophagy in prostate cancer cells by inhibiting the PI3K–Akt–mTOR signaling pathway. Cell Death & Disease, 12(4), 1–12. https://doi.org/10.1038/s41419-021-03588-w Cite
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