Prostate Luminal Progenitor Cells: From Mouse to Human, from Health to Disease

The authors provide an overview of the intrinsic functional properties of luminal progenitor cells, and address their relevance in mouse and human prostate pathophysiology.
[Nature Reviews Urology]
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Optimal Use of Tumor-Based Molecular Assays for Localized Prostate Cancer

The use of genomic testing for prostate cancer continues to grow; however, utilization remains institutionally dependent. Scientists review current tissue-based markers and comment on current use with active surveillance and prostate MRI.
[Current Oncology Reports]
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Dysbiotic Microbes and How to Find Them: A Review of Microbiome Profiling in Prostate Cancer

Investigators provide a detailed overview of the current knowledge of the role of the human microbiome in prostate cancer development, progression, and treatment response.
[Journal of Experimental & Clinical Cancer Research]
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Profound Medical Announces First Patients Treated in Prospective, Randomized Clinical Trial Comparing the TULSA Procedure to Radical Prostatectomy

Profound Medical Corp. announced that the first patients have been treated in the Level 1 ‘CAPTAIN’ trial. CAPTAIN (A Comparison of TULSA Procedure vs. Radical Prostatectomy in Participants with Localized Prostate Cancer) is a prospective, multi-centre randomized controlled trial of 201 patients aimed at comparing the safety and efficacy of the TULSA procedure with radical prostatectomy in men with organ-confined, intermediate-risk, Gleason Score 7 prostate cancer.
[Profound Medical Corp. (GlobeNewswire, Inc.)]
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MiR-378a Inhibits Glucose Metabolism by Suppressing GLUT1 in Prostate Cancer

Researchers explored the prognostic potential and the functional role of microRNAs in localized prostate cancer and their relation to nodal metastasis.
[Oncogene]
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Stage-Specific Differential Expression of Zinc Transporter SLC30A and SLC39A Family Proteins during Prostate Tumorigenesis

Investigators assessed the stage-specific expression of zinc transporters (ZNTs) belonging to the ZNT (SLC30A) and Zrt- and Irt-like protein (SLC39A) solute-carrier family in the prostate tissues of different genetically engineered mouse models of prostate cancer, their age-matched wild-type controls, and 104 prostate core biopsies from human patients with different pathological lesions.
[Molecular Carcinogenesis]
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GDF15 Promotes Prostate Cancer Bone Metastasis and Colonization through Osteoblastic CCL2 and RANKL Activation

Scientists evaluated growth differentiation factor-15 (GDF15) function using in vivo preclinical prostate cancer (PCa)-bone metastasis mouse models and an in vitro bone cell coculture system and suggested that PCa-secreted GDF15 promoted bone metastases and induced bone microarchitectural alterations in a preclinical xenograft model.
[Bone Research]
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MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling

Using human cell lines that represent androgen-independent or -sensitive prostate cancer, the authors showed that mitochondrial Rho GTPase 2 (MIRO2) depletion impaired cell growth, colony formation, and tumor growth in mice.
[Molecular Cancer Research]
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Abiraterone Switches Castration-Resistant Prostate Cancer Dependency from Adrenal Androgens towards Androgen Receptor Variants and Glucocorticoid Receptor Signaling

Abiraterone, an inhibitor of the steroidogenic enzyme CYP17A1, has been demonstrated to reduce adrenal androgen synthesis and prolong CRPC patient survival. To study mechanisms of resistance to castration and abiraterone, researchers created coculture models using human prostate and adrenal tumors.
[Prostate]
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Exosome-Mediated Delivery of Transforming Growth Factor-β Receptor 1 Kinase Inhibitors and Toll-Like Receptor 7/8 Agonists for Combination Therapy of Tumors

Combination therapy with the transforming growth factor-β receptor I kinase inhibitor SD-208 and a toll-like receptor-7/8 agonist resiquimod was examined along with serum-derived exosomes as versatile carriers and may serve as a promising strategy to treat melanoma and prostate cancer.
[Acta Biomaterialia]
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Caffeic Acid Phenethyl Ester Induces Radiosensitization via Inhibition of DNA Damage Repair in Androgen-Independent Prostate Cancer Cells

Investigators studied the effect of co-treatment of caffeic acid phenethyl ester (CAPE) and gamma radiation on androgen-independent DU145 and PC3 cells. The combination treatment sensitized prostate cancer cells to radiation in a dose-dependent manner. The radiosensitizing effect of CAPE was observed in both cell lines.
[Environmental Toxicology]
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