Integrins α6β1 and Bnip3 were found to promote survival of castration-resistant prostate cancer cells selectively on laminin through the induction of autophagy and mitophagy.
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Nollet, E. A., Cardo-Vila, M., Ganguly, S. S., Tran, J. D., Schulz, V. V., Cress, A., Corey, E., & Miranti, C. K. (2020). Androgen receptor-induced integrin α6β1 and Bnip3 promote survival and resistance to PI3K inhibitors in castration-resistant prostate cancer. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-1370-9 Cite
Scientists studied two cell line-derived xenografts and the first 80 patient-derived xenografts (PDXs) derived from 47 human prostate cancer donors. Of these, 47 PDXs derived from 22 donors were working models and could be expanded either as cell lines or PDXs.
[Clinical Cancer Research]
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Palanisamy, N., Yang, J., Shepherd, P. D. A., Li-Ning-Tapia, E. M., Labanca, E., Manyam, G., Ravoori, M., Kundra, V., Araujo, J. C., Efstathiou, E., Pisters, L. L., Wan, X., Wang, X., Vazquez, E. S., Aparicio, A. M., Carskadon, S., Tomlins, S. A., Kunju, L. P., Chinnaiyan, A. M., … Navone, N. M. (2020). The MD Anderson prostate cancer patient-derived xenograft series (MDA PCa PDX) captures the molecular landscape of prostate cancer and facilitates marker-driven therapy development. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-0479 Cite
Researchers observed that two compounds at 10 μΜ significantly inhibited the migratory behavior of the PC3 and DU145 prostate cancer cell lines.
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The effect of glutathione-responsive β-cyclodextrin-based nanosponges (GSH-NS) on cell growth was evaluated on multicellular spheroids and a comparison of the GSH-NS cell growth inhibitory activity was performed between 2D and 3D cell cultures.
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Argenziano, M., Foglietta, F., Canaparo, R., Spagnolo, R., Della Pepa, C., Caldera, F., Trotta, F., Serpe, L., & Cavalli, R. (2020). Biological Effect Evaluation of Glutathione-Responsive Cyclodextrin-Based Nanosponges: 2D and 3D Studies. Molecules, 25(12), 2775. https://doi.org/10.3390/molecules25122775 Cite
In VCaP prostate cancer cells, both splice-switching oligonucleotides were effective at inducing exon 4 skipping, which resulted in a reduction of overall ERG protein levels up to 96 hours following a single transfection.
[British Journal of Cancer]
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Li, L., Hobson, L., Perry, L., Clark, B., Heavey, S., Haider, A., Sridhar, A., Shaw, G., Kelly, J., Freeman, A., Wilson, I., Whitaker, H., Nurmemmedov, E., Oltean, S., Porazinski, S., & Ladomery, M. (2020). Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer. British Journal of Cancer, 1–9. https://doi.org/10.1038/s41416-020-0951-2 Cite
Transfection of miR‑30c mimicked into prostate cancer cells resulted in reduced cell viability, increased proportion of cells in the G1 phase and higher apoptotic rates.
Combination with the BAD-like mimetic ABT-737 was examined on prostate cancer cells and 3D spheroids and in view of tumor growth and survival in the prostate cancer SCID mouse xenograft model.
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Both CHK1 inhibitors significantly potentiated the sensitivity to gemcitabine in a panel of chemo‐naïve and matched docetaxel‐resistant prostate cancer cell lines under 2D conditions.
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Drápela, S., Khirsariya, P., Weerden, W. M. van, Fedr, R., Suchánková, T., Búzová, D., Červený, J., Hampl, A., Puhr, M., Watson, W. R., Culig, Z., Krejčí, L., Paruch, K., & Souček, K. (n.d.). The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe. Molecular Oncology, n/a(n/a). https://doi.org/10.1002/1878-0261.12756 Cite
The destabilization of androgen receptor-checkpoint kinase 2 (CHK2) interactions induced by CHK2 variants impaired CHK2 negative regulation of cell growth.
On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.