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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
Recent Progress in Neonatal Hyperoxic Lung Injury
[Pediatric Pulmonology] Investigators analyze and summarize sex differences in neonatal hyperoxic lung injury, potential pathogenesis, and treatment progress to provide new ideas for basic and clinical research in this field.
First In Vitro Measurement of VHEE Relative Biological Effectiveness (RBE) in Lung and Prostate Cancer Cells Using the ARES Linac at DESY
[Scientific Reports] Investigators explored how electrons in the very high energy electrons (VHEE) range could be used to perform successful in vitro radiobiological studies.
Divarasib in the Evolving Landscape of KRAS G12C Inhibitors for NSCLC
[Targeted Oncology] Kristen Rat Sarcoma viral oncogene (KRAS) mutations are one of the most common oncogenic drivers found in 12–14% of NSCLC and 4% of colorectal cancer tumors.
A Virus-Inspired Inhalable Liponanogel Induces Potent Antitumor Immunity and Regression in Metastatic Lung Tumors
[Cancer Research] Inspired by the structure of a virus that utilized internal viral proteins to tune the loading and cytosolic delivery of viral nucleic acids, scientists developed a liponanogel-based platform to overcome the delivery challenges of poly(I:C).
Downregulation of Mirlet7 miRNA Family Promotes Tc17 Differentiation and Emphysema via De-repression of RORγt
[eLife] The authors demonstrated that loss of the Mirlet7b/Mirlet7c2 cluster in T cells predisposed mice to exaggerated cigarette smoke- or nanosized carbon black-elicited emphysema.
Iron Overload–Dependent Ferroptosis Aggravates LPS-Induced Acute Lung Injury by Impairing Mitochondrial Function
[Inflammation] Investigators observed a significant increase in iron concentration during acute lung injury, accompanied by elevated levels of lipid peroxidation markers such as malonaldehyde and 4-hydroxynonenal.
β-Catenin Turnover Is Regulated by Nek10-Mediated Tyrosine Phosphorylation in A549 Lung Adenocarcinoma Cells
[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators observed that deletion of Nek10 in lung adenocarcinoma cells resulted in dramatic stabilization of β-catenin, suggestive of a Nek10 role in the control of β-catenin turnover.
The Role of Gut-Lung Axis in COPD: Pathogenesis, Immune Response, and Prospective Treatment
[Heliyon] The authors summarize how the gut-lung axis influences COPD, including the alterations of intestinal microecology, the pathological mechanisms, and the involved immune responses.
Alectinib Approved as an Adjuvant Treatment for Lung Cancer
[National Cancer Institute] Based on the ALINA trial results, the FDA approved alectinib as adjuvant therapy for people with ALK-positive NSCLC.
Prime Editing Functionally Corrects Cystic Fibrosis-Causing CFTR Mutations in Human Organoids and Airway Epithelial Cells
[Cell Reports Medicine] Scientists presented prime editing approaches to correct L227R- and N1303K-CFTR, two mutations that caused cystic fibrosis and were not eligible for current market-approved modulator therapies.
Assessing Personalized Responses to Anti-PD-1 Treatment Using Patient-Derived Lung Tumor-on-Chip
[Cell Reports Medicine] The authors presented the development and validation of lung tumor-on-chip platforms to quickly and precisely measure ex vivo the effects of immune checkpoint inhibitors on T cell-mediated cancer cell death by exploiting the power of live imaging and advanced image analysis algorithms.
HMGN1 Loss Sensitizes Lung Cancer Cells to Chemotherapy
[Scientific Reports] Integrative analyses of multiple-omics data revealed that high mobility group nucleosome binding (HMGN) frequently exhibit dysregulation in lung adenocarcinoma (LUAD). Subsequent analysis of the clinical relevance of HMGN1 demonstrated its association with poor prognosis in LUAD and its potential as a diagnostic marker to differentiate LUAD from healthy controls.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
