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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
Emerging Roles of Exosomal circRNAs in Non-Small Cell Lung Cancer
[Journal of Translational Medicine] The authors briefly introduce the biogenesis, characterizations, and functions of circRNAs and exosomes, and systematically describes the biological functions and mechanisms of exosomal circRNAs in NSCLC.
Roche Receives FDA Breakthrough Label for AI-Powered Lung Cancer Companion Diagnostic Test
[Fierce Biotech] Roche has claimed a breakthrough designation from the FDA for a cancer test that combines an antibody assay with artificial-intelligence-powered analysis to provide what the company says could become the agency’s first AI-driven companion diagnostic for NSCLC.
Molecular Characteristics and Responses to EGFR/em> Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Patients with EGFR Exon 19 Insertions
[BMC Medicine] Next-generation sequencing was performed to profile the molecular characteristics of 83 NSCLC patients with EGFR 19ins.
SETD5 Facilitates Stemness and Represses Ferroptosis via m6A-Mediating PKM2 Stabilization in Non-Small Cell Lung Cancer
[Oncogene] Scientists employed the NSCLC tissue microarray and bioinformatics tools to analyze SETD5 expression and determine its effect on stemness and investigated the role of SETD5 in the metastasis of NSCLC using in vitro and in vivo analyses.
Zongertinib in Previously Treated HER2-Mutant Non–Small-Cell Lung Cancer
[New England Journal of Medicine] Investigators evaluated zongertinib in a multicohort, phase Ia–Ib trial involving patients with advanced or metastatic HER2-mutant NSCLC.
Personalized Inhaled Bacteriophage Therapy for Treatment of Multidrug-Resistant Pseudomonas aeruginosa in Cystic Fibrosis
[Nature Medicine] Using a personalized phage therapy strategy that selected phages for a predicted evolutionary trade-off, nine adults with cystic fibrosis were treated with phages on a compassionate basis because their clinical course was complicated by multidrug-resistant or pan-drug-resistant Pseudomonas.
FAT1 Enhances the Sensitivity of Non-Small Cell Lung Cancer to VCP Inhibitors by Regulating the Activation of the Endoplasmic Reticulum Stress Pathway
[FASEB Journal] Scientists observed that among compounds related to protein homeostasis, the valosin-containing protein (VCP) inhibitor CB-5083 demonstrated the most significant variation in sensitivity among NSCLC cells, categorized according to FAT atypical cadherin 1 (FAT1) expression levels.
Prolonged Airway Explant Culture Enables Study of Health, Disease, and Viral Pathogenesis
[Science Advances] Investigators described methods to culture human large airway explants, small airway explants, and precision-cut lung slices for at least 14 days.
In Vivo Functional Screens Reveal KEAP1 Loss As a Driver of Chemoresistance in Small Cell Lung Cancer
[Science Advances] As small cell lung cancer patient-derived xenograft (PDX) models mimic therapeutic responses, scientists performed genetic screens in chemosensitive PDX models to identify drivers of chemoresistance.
Fangchinoline-Mediated Autophagy Inhibition Amplifies Antigen Presentation and PD-1 Blockade Efficacy in Lung Cancer
[Acta Pharmacologica Sinica] Researchers investigated the modulatory effects of PD-1 blockade combined with fangchinoline on CD8+ T cells within the tumor microenvironment of lung cancer.
Proteostasis Landscapes of Cystic Fibrosis Variants Reveal Drug Response Vulnerability
[Proceedings of The National Academy of Sciences of The United States of America] Using high-throughput interactomics, Rosetta simulations, and biochemical trafficking assays, scientists showed that poorly responsive cystic fibrosis variants experienced diverse misfolding pathways caused by structural defects in the core of a nucleotide-binding domain.
A METTL3-NFE2L3 Axis Mediates Tumor Stemness and Progression in Lung Adenocarcinoma
[Science Advances] Investigators identified that OV6+ tumor cells exhibited stem-like characteristics and were notably enriched in patients with non–major pathological response, closely associated with resistance to combination therapies.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
