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Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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Dysregulated Alveolar Type 2 Epithelial Cell Proteostasis Promotes Fibrogenic Macrophage Migration Inhibitory Factor-CD74 Signaling
[Science Translational Medicine] Scientists showed that ubiquitin-proteasome system disruption in alveolar type 2 epithelial cells amplifies profibrotic signaling to macrophages through macrophage migration inhibitory factor family proteins in several models.
Methylated circPTK2 As a Driver of Fibroblast Activation in Pulmonary Fibrosis
[Molecular Therapy] Researchers identified circPTK2, a fibroblast-specific circular RNA that is significantly upregulated in pulmonary fibrosis patients and experimental models.
High-Throughput Isolation of Normal and Pulmonary Fibrosis Human Alveolar Epithelial Cells
[Scientific Reports] Investigators presented a comprehensive workflow for the isolation and culture of primary human AT2 cells, including an efficient enzyme-based lung tissue digestion protocol and automated purification of human alveolar type 2 cells from both healthy and diseased lungs.
KDM6B Induces Demethylation of H3K27me3 in MFN1 to Modulate Aberrant Mitophagy in Sepsis-Induced Acute Lung Injury
[Scientific Reports] The authors investigated the impact of KDM6B on macrophage processes during sepsis-induced acute lung injury and elucidated the underlying molecular mechanisms.
Genomic and Transcriptomic Dynamics in the Stepwise Progression of Lung Adenocarcinoma
[Cell Research] Researchers performed whole-genome and transcriptome sequencing on 1008 lung adenocarcinoma samples from 954 patients who underwent surgery at Fudan University Shanghai Cancer Center, with comprehensive follow-up data.
Steric Disruption of EGFR Oligomerization Overcomes Therapy Resistance in Non-Small Cell Lung Cancer
[Science Advances] Scientists investigated the real-time link between oligomerization of oncogenic and resistant epidermal growth factor receptor (EGFR) mutants and downstream signaling using a fluorescent protein–based proximity probe and signaling reporter in living cells.
circATF6 Triggers Calcium Overload to Synergize with EGFR-TKI in Non-Small Cell Lung Cancer via Modulation of Proteostasis
[Cell Reports] The authors identified the circular RNA circATF6, which is specifically downregulated in drug-tolerant persister cells due to regulation by the splicing factor ADAR1.
Cytoskeletal Remodeling via CAMSAP3 Downregulation Drives Resistance to Osimertinib in NSCLC Cells
[Cell Death & Disease] Researchers found that centrosomal microtubule formation was increased in osimertinib-resistant NSCLC cells, and calmodulin-regulated spectrin-associated protein 3 (CAMSAP3) was identified as the key molecule responsible for the change of microtubule morphology.
Application and Prospects of Lung Organ-on-a-Chip in the Development of New Drugs
[Biomedical Engineering Online] Investigators focus on the structure and the composition of supporting cells of organ-on-a-chip, whose most notable feature is its biomimetic representation of the human body.
JASCAYD® (Nerandomilast) Receives First Regulatory Approval for Progressive Pulmonary Fibrosis in China
[Boehringer Ingelheim] China’s National Medical Products Administration has approved JASCAYD® as the first new treatment for adults with progressive pulmonary fibrosis in more than five years, marking a breakthrough for millions affected by the life-threatening lung condition.
A Ferret Model Demonstrates Sustained Fibrosis, Restrictive Physiology, and Airway Proximalization
[NPJ Regenerative Medicine] Researchers evaluated ferrets exposed to a single dose of bleomycin longitudinally, and found sustained restrictive physiology, increased opacification and fibrotic injury in the lungs through 22 weeks.
Transcription Factor CEBPA Suppresses Sepsis Induced Lung Injury by Activating SIRT4 Transcription
[Scientific Reports] The authors investigated the roles of the transcription factor CEBPA and the sirtuin family protein SIRT4 in sepsis-induced acute lung injury through both cell-based experiments and animal models.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
