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Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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p53 Drives Lung Cancer Regression through a TSC2/TFEB-Dependent Senescence Program
[Cancer Discovery] Scientists used mouse and human models to deconstruct the transcriptional programs and sequelae underlying robust therapeutic responses in lung adenocarcinoma.
KLF5 Activation Promotes Malignant Transformation to Drive Development of Lung Squamous Cell Carcinoma
[Cancer Research] Researchers used genetically engineered organoids to identify the function of KLF5 in tumorigenesis of multiple endodermal epithelial cancers.
Targeted Metabolism Creates Possibilities for Lung Cancer Treatment in the Precision Tumor Era
[Respiratory Research] Scientists summarize the latest research in glucose metabolism, lipid metabolism, protein metabolism, and nucleotide metabolism in lung cancer.
Fox Chase Cancer Center and Omniscope Announce Research Collaboration to Advance Non-Small Cell Lung Cancer Immunotherapy Development
[Fox Chase Cancer Center] Fox Chase Cancer Center and Omniscope announced a new research collaboration aimed at identifying novel biomarkers for immune checkpoint inhibitor response in NSCLC.
Rab43 Mitigates the Inflammatory Response in Acute Lung Injury via MyD88 Ubiquitination
[Scientific Reports] Myeloid-specific Rab43 knockout mice were generated and used to construct a mouse model of acute lung injury after airway administration by lipopolysaccharides.
KMT2D Loss Drives Adeno-to-Squamous Transition and Sensitizes TKI-Resistant Lung Cancer to AURKA Inhibition
[Cell Death & Differentiation] The authors identified loss of the histone methyltransferase KMT2D as a critical event that disrupts adenocarcinoma lineage fidelity and promotes squamous transition.
An H4K12la/CEBPB-AKR1C2 Signaling Axis Modulates the mTOR Pathway to Regulate Cisplatin Resistance in Lung Cancer
[Oncogene] Scientists demonstrated that histone lactylation is closely associated with cisplatin resistance and correlates with poor prognosis of NSCLC.
HDAC6 Orchestrates Metastatic and Immunosuppressive Programs in Small Cell Lung Cancer through S100A2-TGF-β/SMAD and CSF1R Signaling
[Molecular Cancer] Preclinical SCLC models were utilized alongside molecular, cellular, and immunological techniques to elucidate histone deacetylase 6 (HDAC6)'s mechanistic functions.
UCHL1 Stabilizes Twist1 via K11/K63-Linked Deubiquitination to Drive Tumor Metastasis in Non-Small Cell Lung Cancer
[Cell Death Discovery] Scientists demonstrated that ubiquitin C-terminal hydrolase L1 (UCHL1) is upregulated in NSCLC and drives tumor metastatic progression.
Sbno2-Mediated Tissue-Resident Alveolar Macrophages: A Novel Therapeutic Axis for Sepsis-Induced Acute Lung Injury
[Cell Death Discovery] Researchers investigated the role of Sbno2-expressing tissue-resident alveolar macrophages in promoting alveolar epithelial cell regeneration and barrier function in sepsis-induced acute lung injury.
PARP1 Stabilizes FOXN3 to Suppress Pulmonary Fibrosis through p38-Related Feedback Regulation
[Science Advances] Investigators identified poly(ADP-ribose) polymerase–1 (PARP1) as a stabilizing partner of FOXN3, preventing its degradation by blocking p38-mediated phosphorylation.
MRPL17 Is a Critical Regulator of Mitochondrial Function and a Novel Therapeutic Target in Non-Small Cell Lung Cancer
[Cell Death & Disease] Researchers investigated the role of the mitochondrial protein mitochondrial ribosomal protein L17 (MRPL17) in NSCLC, exploring its expression profile, clinical significance, and therapeutic potential.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
