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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
Air Pollution and Alveolar Health
[European Respiratory Review] In recent years, evidence has emerged identifying a role in the development and progression of sub-clinical interstitial lung abnormalities as well as progression and risk of exacerbation of fibrotic interstitial lung diseases.
Particulate Matter Air Pollution: Effects on the Respiratory System
[Journal of Clinical Investigation] The authors review the epidemiological evidence linking particulate matter exposure and lung diseases including asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, pneumonia, acute respiratory distress syndrome, and lung cancer.
5-HT Regulates Resistance to Aumolertinib by Attenuating Ferroptosis in Lung Adenocarcinoma
[EMBO Molecular Medicine] Scientists found that HER2 S310F mutation contributes to third-generation epidermal growth factor receptor-tyrosine kinase inhibitor resistance, driven by the accumulation of neurotransmitter 5-hydroxytryptamine (5-HT).
Caspase-9 Activates β-Catenin Signaling to Promote Pulmonary Fibrosis
[Journal of Translational Medicine] Using both bleomycin-induced mouse models and TGF-β-stimulated alveolar epithelial cells, researchers examined the expression, activity, and pathological significance of caspase-9.
EML4-ALK Rearrangement Creates a Distinctive Myeloid Cell-Dominant Immunosuppressive Microenvironment in Lung Cancer
[Cancer Immunology Research] An IL6R inhibitor transformed the tumor microenvironment in a murine anaplastic lymphoma kinase (ALK)+ lung adenocarcinoma model, shifting it from an immunosuppressive to a T cell–dominant status.
High-Fidelity Cas9-Mediated Targeting of KRAS Driver Mutations Restrains Lung Cancer in Preclinical Models
[Nature Communications] Investigators developed a CRISPR-High Fidelity-Cas9-based therapy strategy that can effectively and specifically target KRASG12C and KRASG12D mutants, avoiding KRASWT off-targeting and affecting KRAS downstream pathways, thereby significantly reducing tumorgenicity.
Michael J. Welsh, MD, Receives Yergin-New International Prize for Biomedical Research
[The Icahn School of Medicine at Mount Sinai] The Icahn School of Medicine at Mount Sinai will award its 2025 Yergin-New International Prize for Biomedical Research to Michael J. Welsh, MD, of the University of Iowa for his pioneering work in cystic fibrosis, which has significantly advanced understanding and treatment of this chronic, inherited lung disease with an onset in children.
Lilly’s Olomorasib Receives US FDA’s Breakthrough Therapy Designation for the Treatment of Certain Newly Diagnosed Metastatic KRAS G12C-Mutant Lung Cancers
[Eli Lilly and Company] Eli Lilly and Company announced that the US FDA has granted Breakthrough Therapy designation to olomorasib, in combination with anti-PD-1 therapy KEYTRUDA for the first-line treatment of patients with unresectable advanced or metastatic NSCLC with a KRAS G12C mutation and PD-L1 expression ≥ 50%.
Clonal Expansion of Alveolar Fibroblast Progeny Drives Pulmonary Fibrosis in Mouse Models
[Journal of Clinical Investigation] Through EdU incorporation, genetic lineage tracing, and single cell RNA sequencing, researchers resolve the proliferation dynamics of lung fibroblasts during post-injury fibrogenesis.
Damon Runyon Cancer Research Foundation Awards $4.8 Million to Exceptional Early-Career Scientists
Intestinal Cell NewsMammary Cell NewsNeural Cell NewsNewslettersProstate Cell NewsPulmonary Cell News
[Damon Runyon Cancer Research Foundation] The Damon Runyon Cancer Research Foundation has named 16 new Damon Runyon Fellows. This fellowship encourages young scientists to pursue careers in cancer research by providing them with independent funding to investigate cancer causes, mechanisms, therapies, and prevention.
A “Space-for-Time” Strategy Based on Single-Cell Dual-Isotope ICP-MS Analysis Enabling High-Throughput and Sensitive Quantification of miRNAs in Breast Cancer Cells for Therapeutic Assessment
Intestinal Cell NewsMammary Cell NewsNeural Cell NewsNewslettersProstate Cell NewsPulmonary Cell News
[Analytical Chemistry] Investigators focused on two key regulatory miRNAs in breast cancer therapeutic assessment and developed a “space-for-time” strategy using dual-isotope ICP-MS for single-cell miRNAs quantification.
Prolonging Lung Cancer Response to EGFR Inhibition by Targeting the Selective Advantage of Resistant Cells
[Nature Communications] Through a DNA barcoding approach, scientists showed that the clinically approved drug sorafenib specifically abolishes the selective advantage of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)-resistant cells, while preserving the response of EGFR-TKI-sensitive cells.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
