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Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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A Ferret Model Demonstrates Sustained Fibrosis, Restrictive Physiology, and Airway Proximalization
[NPJ Regenerative Medicine] Researchers evaluated ferrets exposed to a single dose of bleomycin longitudinally, and found sustained restrictive physiology, increased opacification and fibrotic injury in the lungs through 22 weeks.
Transcription Factor CEBPA Suppresses Sepsis Induced Lung Injury by Activating SIRT4 Transcription
[Scientific Reports] The authors investigated the roles of the transcription factor CEBPA and the sirtuin family protein SIRT4 in sepsis-induced acute lung injury through both cell-based experiments and animal models.
GLMP Promotes EGFR-TKI Resistance by Activating Autophagy and RhoA Pathway in Non-Small Cell Lung Cancer
[npj Precision Oncology] Investigators reported that the epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance mechanism is mediated by lysosome-related regulation.
Protein Kinase Cι Dictates Tumor Trajectory, Cell Plasticity, and Immune Surveillance in Lung Adenocarcinoma
[Cell Reports] Researchers demonstrated that genetic loss of protein kinase Cι alters the trajectory of mouse Kras/Trp53-driven lung adenocarcinoma tumors from one resembling lung development to one mimicking lung regeneration.
SOS1 Inhibition Suppresses the Emergence of Osimertinib Resistance to Generate a Durable Response in EGFR-Mutant Lung Cancer
[Science Signaling] The authors found that inhibiting the proximal receptor tyrosine kinase signaling intermediate SOS1 promoted continued osimertinib efficacy in sensitive cells and restored sensitivity in cells with acquired resistance.
A Positive Feedback Loop between TNS1 and ZEB1 Promotes TGFβ-induced Epithelial-to-Mesenchymal Transition in Lung Cancer
[Communications Biology] Researchers identified that tensin-1 (TNS1) is upregulated in a TGFβ-induced epithelial-mesenchymal transition cell model.
Construction of the Cancer Cell Continuum Reveals Hybrid EMT State Driving Lung Adenocarcinoma Aggression
[Cancer Gene Therapy] Investigators reconstructed the epithelial-to-mesenchymal transition (EMT) spectrum in lung adenocarcinoma by integrating single-cell RNA sequencing data with advanced cell trajectory inference techniques.
Applications and Complementarity of Organ-Chips and Animal Models in Lung Cancer Driver Gene Research
[Cell Biology International] The authors summarize and compare previous studies of the application and complementarity of organ-chip technologies and traditional animal models for investigating the same genetic alterations.
FDA Approves First Cancer Drug Based on Broad Institute Science
[Broad Institute] The US FDA has approved sevabertinib, which was developed by Bayer Healthcare Pharmaceuticals in close collaboration with the Broad, and is the first FDA-approved medicine from the long-standing Broad-Bayer oncology research alliance.
The Deubiquitinase OTUD1 Orchestrates Cisplatin Chemosensitivity of Non-Small Cell Lung Cancer through Destabilizing RAD23B/XPC
[Oncogene] Scientists uncovered that OTU deubiquitinase 1 (OTUD1) plays an important role in orchestrating cisplatin chemosensitivity of NSCLC.
Mesenchymal Stromal Cells Engineered with ACE2 for Treatment of Receptor-Mediated Viral Lung Injury
[Molecular Therapy] Scientists engineered MSCs expressoing human ACE2, designed to couple direct antiviral activity with immonoregulation.
The N6-Methyladenosine-Mediated cLMNB1 Degrades FGFR4 to Overcome Osimertinib Resistance in Non-Small Cell Lung Cancer
[Cell Death & Disease] Researchers observed that circRNA LMNB1 increases the sensitivity of lung adenocarcinoma to osimertinib in vitro and in vivo.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
