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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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A Molecular Circuit Regulates Fate Plasticity in Emerging and Adult AT2 Cells
[Nature Communications] Researchers showed in the embryonic lung that single alveolar type 2 (AT2) cells emerge at intermediate zones, extrude, and connect with nearby epithelium via interlumenal junctioning.
Hypoxia Promotes Airway Differentiation in the Human Lung Epithelium
[Cell Stem Cell] Using chemical and genetic tools, scientists demonstrated that hypoxia-induced airway differentiation depends on hypoxia-inducible factor (HIF) activity, with HIF1α and HIF2α differentially regulating progenitor fate decisions.
Spliceosome Inhibition Induces Z-RNA and ZBP1-Driven Cell Death in Small Cell Lung Cancer
[Cell Reports] Scientists showed that spliceosome inhibition by pharmacological or genetic neutralization of SF3B1 activity induces the accumulation of endogenous left-handed dsRNAs (Z-RNAs) derived from intron-retained RNAs.
A Small Molecule Targets LIC1 to Suppress Lung Tumor Growth by Inducing Autophagy
[Nature Chemical Biology] Investigators identified a potent autophagy inducer 3,4-diisobutyryl derivative of auxarthrol A from an endophyte-derived small-molecule library.
P2X7 Receptor: A Potential Therapeutic Target for Chronic Respiratory Diseases
[Molecular and Cellular Biochemistry] The authors comprehensively summarize the structure and functions of purinergic ligand-gated ion channel 7 receptor (P2X7R) as well as its roles and potential molecular mechanisms in chronic respiratory diseases.
The CCL20-Integrin α5β1 Interaction Enhances TGF-β/Smad Signaling to Promote Fibroblast Activation in Pulmonary Fibrosis
[Nature Communications] Researchers found that chemokine CCL20 expression is increased in both murine models and patients with pulmonary fibrosis.
Chiesi Announces FDA Acceptance of New Drug Application for its Triple Combination Inhaler for the Maintenance Treatment of Asthma
[Chiesi USA, Inc. (Globe Newswire)] Chiesi USA, Inc. announced that the US FDA has accepted the company’s New Drug Application for its investigational maintenance treatment of asthma in adults.
mTOR Dysregulation Induces IL-6 and Paracrine AT2 Cell Senescence Impeding Lung Repair in Lymphangioleiomyomatosis
[Nature Communications] The authors examined if mTOR dysregulation can induce senescence and impair the response to lung injury in lymphangioleiomyomatosis.
A Cellular and Spatial Atlas of TP53-Associated Tissue Remodeling Defines a Multicellular Tumor Ecosystem in Lung Adenocarcinoma
[Nature Cancer] To define how TP53 mutations affect the LUAD tumor microenvironment, scientists constructed a multiomic cellular and spatial atlas of 23 treatment-naive human lung tumors.
Role of Ferroptosis on Lung Epithelial Cells in Disease Progression and Treatment: A Review
[Medical Science Monitor] Investigators review the role of epithelial cell ferroptosis in benign and malignant lung diseases.
Two Scientists Receive LCRF | Bayer Lung Cancer Research Awards
[Lung Cancer Research Foundation (LCRF)] The Lung Cancer Research Foundation (LCRF) announced, in collaboration with Bayer Pharmaceuticals, the recipients of two research grants focused on innovative strategies to advance the understanding and management of lung cancers harboring HER2 mutations and/or other HER2 alterations.
Mutant RIT1 Cooperates with YAP to Drive an EMT-Like Lung Cancer State
[Cell Reports] Investigators showed that autochthonous expression of RIT1M90I and combined inactivation of Nf2 and p53 drives an aggressive lung cancer with 100% penetrance and short latency.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
