Scientists unravelled the down-stream pathways associated with mitochondrial complex II (CII) inhibition and compared with CI inhibition and the Manganese neurotoxicity. Genome-wide transcriptomics of N27 neuronal cells exposed to 3-nitropropionic acid, compared with 1-methyl-4-phenylpyridinium and Mn revealed varied transcriptomic profile.
[Scientific Reports]
Ranganayaki, S., Jamshidi, N., Aiyaz, M., Rashmi, S.-K., Gayathri, N., Harsha, P. K., Padmanabhan, B., & Srinivas Bharath, M. M. (2021). Inhibition of mitochondrial complex II in neuronal cells triggers unique pathways culminating in autophagy with implications for neurodegeneration. Scientific Reports, 11(1), 1483. https://doi.org/10.1038/s41598-020-79339-2 Cite
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