Multiplexed Analysis of Neural Cytokine Signaling by a Novel Neural Cell–Cell Interaction Microchip

The authors generated a neural cell-cell interaction microchip as an in vitro platform to simultaneously track an informed panel of cytokines and co-evaluate cell morphology and biomarker expression coupled to a sandwich ELISA platform.
[Lab on a Chip]
Abdullah, M. A. A., Amini, N., Yang, L., Paluh, J. L., & Wang, J. (2020). Multiplexed analysis of neural cytokine signaling by a novel neural cell–cell interaction microchip. Lab on a Chip. https://doi.org/10.1039/D0LC00401D Cite
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The Effects of Microglia‐ and Astrocyte‐Derived Factors on Neurogenesis in Health and Disease

The authors describe how glial cells play a role in adult hippocampal neurogenesis in both health and disease, especially focusing on glia‐derived factors.
[European Journal of Neuroscience]
Araki, T., Ikegaya, Y., & Koyama, R. (2020). The effects of microglia‐ and astrocyte‐derived factors on neurogenesis in health and disease. European Journal of Neuroscience. https://doi.org/10.1111/ejn.14969 Cite
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Reversal of Pre-Existing NGFR-Driven Tumor and Immune Therapy Resistance

Researchers chronically exposed patient-derived melanoma cell lines to differentiation antigen-specific cytotoxic T cells and observed strong enrichment of a pre-existing NGFRhi population.
[Nature Communications]
Boshuizen, J., Vredevoogd, D. W., Krijgsman, O., Ligtenberg, M. A., Blankenstein, S., de Bruijn, B., Frederick, D. T., Kenski, J. C. N., Parren, M., Brüggemann, M., Madu, M. F., Rozeman, E. A., Song, J.-Y., Horlings, H. M., Blank, C. U., van Akkooi, A. C. J., Flaherty, K. T., Boland, G. M., & Peeper, D. S. (2020). Reversal of pre-existing NGFR-driven tumor and immune therapy resistance. Nature Communications, 11(1), 3946. https://doi.org/10.1038/s41467-020-17739-8 Cite
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Astrocytic BDNF and TrkB Regulate Severity and Neuronal Activity in Mouse Models of Temporal Lobe Epilepsy

Specific genetic deletion of BDNF in astrocytes prevented the increase in the number of firing neurons and the global firing rate in an in vitro model of temporal lobe epilepsy.
[Cell Death & Disease]
Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy | Cell Death & Disease. (n.d.). Retrieved June 4, 2020, from https://www.nature.com/articles/s41419-020-2615-9 Cite
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Astrocytic BDNF and TrkB Regulate Severity and Neuronal Activity in Mouse Models of Temporal Lobe Epilepsy

Specific genetic deletion of BDNF in astrocytes prevented the increase in the number of firing neurons and the global firing rate in an in vitro model of temporal lobe epilepsy.
[Cell Death & Disease]
Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy | Cell Death & Disease. (n.d.). Retrieved June 4, 2020, from https://www.nature.com/articles/s41419-020-2615-9 Cite
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