EMT

[Journal of Experimental & Clinical Cancer Research] Investigators generated organoids from circulating tumor cells isolated from an orthotopic colorectal cancer xenograft model.

[Cell Death & Disease] Researchers analyzed murine and human tumors and identified a role for Tgfβr2 in governing the molecular aspects of epithelial to mesenchymal transition that occured with Brca1 loss.

[Journal of Cellular and Molecular Medicine] To examine the contribution of siRNA-induced knockdown of CD44 to the biological features of colorectal CSCs, colorectal CSCs HCT116-CSCs were generated, and CD44 was knocked down in HCT116-CSCs using siRNA.

[International Journal of Biological Macromolecules] The authors discuss the role of TGF-β signaling in proliferation, metastasis and therapy response of prostate cancer cells and in order to improve knowledge towards its regulation, upstream mediators of TGF-β such as non-coding RNAs are described.

[Cell Death & Disease] The authors studied the specific function of Numb-PRRL isoform in activated EMT of pancreatic ductal adenocarcinoma, which was distinguished from our previous studies that only focused on the total Numb protein.

[Cell Death & Disease] Through bioinformatics analysis and clinical sample verification, investigators discovered that Stathmin 1 gene was significantly up-regulated at the locations of microvascular invasion.