NASH

[Autophagy] It is still unknown how hepatic inflammation regulates lipid metabolism in hepatocytes. Scientists found that PA treatment or direct stimulation of STING1 promoted, whereas STING1 deficiency impaired, MTORC1 activation, suggesting that STING1 was involved in PA-induced MTORC1 activation.

[Diabetes] Scientists showed genetic deletion and viral knockdown of hepatocyte-specific endothelial nitric oxide synthase (eNOS) exacerbated hepatic steatosis and inflammation, decreased hepatic mitochondrial fatty acid oxidation and respiration, increased mitochondrial H2O2 emission, and impaired the hepatic mitophagic response.

[89bio, Inc.] 89bio, Inc announced that it has completed target enrollment of 20 patients in the paired-biopsy, open-label histology cohort in biopsy-confirmed fibrosis stage F2 – F3 NASH patients.

[Stem Cell Research & Therapy] Scientists examined the effect human amniotic epithelial cells have on the liver progenitor cell response and hepatic oxidative stress in an experimental model of non-alcoholic steatohepatitis.

[Acta Pharmacologica Sinica] Researchers evaluated the therapeutic potential of givinostat, a histone deacetylase inhibitor, in the treatment of nonalcoholic steatohepatitis in vivo and in vitro.

[Advanced Drug Delivery Reviews] Reseachers overview recent findings from human study and animal models on the pathophysiological communication among hepatocytes, Kupffer cells, hepatic stellate cells and liver sinusoidal endothelial cells during the disease development.