TRPV4

[Journal of Pharmacology and Experimental Therapeutics] The ability of GSK2798745 to block TRPV4 agonist GSK1016790-induced impendence reduction in human umbilical vein endothelial cells in the presence of human whole blood was assessed.

[Communications Biology] Reseachers demonstrated functional expression of TRPV4 in mouse schwann cells and investigated its physiological significance.

[Scientific Reports] TRPV4 strongly colocalized and interacted with skeletal protein-F-actin at cellular protrusions, and TRPV4 regulated the formation of invadopodia and filopodia in glioblastoma cells.