YAP

[Science Signaling] Researchers reported the identification of a previously uncharacterized oncogenic signaling pathway in hepatocellular carcinoma that was mediated by the tyrosine kinase Yes.

[Cell Reports] Investigators reported an epithelium-intrinsic requirement for Zeb1, a core transcriptional inducer of epithelial-to-mesenchymal transition, for mammary epithelial ductal side branching and for basal cell regenerative capacity.

[Biomedicine & Pharmacotherapy] Scientists discuss the latest developments in breast cancer stem cells (BCSCs) research, focusing on the analysis of specific markers, critical signaling pathways that maintain the stemness of BCSCs, such as NOTCH, Wnt/β-catenin, STAT3, Hedgehog, and Hippo-YAP signaling.

[Cell Reports] The authors found that CDC42 loss initiated in the intestinal stem cell caused a drastic hyperproliferation of transit amplifying cells and disrupted epithelial polarity.

[Developmental Cell] Scientists showed that in a high-turnover tissue, severe damage to the differentiated compartment induced progenitors to transiently acquire a unique transcriptional and morphological postmitotic state.

[Cell Death Discovery] Researchers explored the potential functions of hypoxia-induced upregulation of Fascin-1 in liver cancer and found that Fascin-1 was upregulated by hypoxia in liver cancer cell lines, elevated in liver cancer patients and correlated with larger tumor size, lymph node metastasis, distant metastasis, and shorter overall survival.