breast cancer cells

[Clinical and Experimental Medicine] The authors investigated pseudopodium-enriched atypical kinase 1 (PEAK1) expression in breast cancer and its role in breast cancer cells in vitro and in vivo and analyzed the relationship with clinicopathological status and chemotherapy resistance.

[Pharmacology & Therapeutics] Investigators discuss the roles of ferroptosis-associated modulators glutathione, glutathione peroxidase 4, iron, nuclear factor erythroid-2 related factor-2, superoxide dismutases, lipoxygenase and coenzyme Q in breast cancer and provide evidence that ferroptosis inducers eliminate breast cancer cells.

[Oncogenesis] Scientists identified nine cancer cell subclusters including CD44+/ALDH2+/ALDH6A1+ breast cancer stem cells, which had a copy-number variants profile similar to that of normal breast tissue.

[European Journal of Cancer] Murine breast cancer cells were grown in both immune-competent and -deficient BALB/c mice, and tumors were irradiated by three fractions of 24 Gy. A PD-1 blockade and a phosphoinositide 3-kinase (PI3K)γδ inhibitor were then administered every other day for two weeks.

[Cell Death Discovery] Researchers showed that the transcripts of Gadd45 family genes, including Gadd45a, Gadd45b, and Gadd45g, were gradually increased upon mouse ESC differentiation. Upregulation of Gadd45 members decreased cell proliferation and induced endodermal and trophectodermal lineages.

[Cell Death Discovery] The authors showed that ERRFI1 was upregulated in sensitive hepatocellular carcinoma (HCC) cells, but not in resistant HCC cells, in response to tryptophan deficiency, and ERRFI1 expression level positively correlated with HCC patient overall survival.