A Concise Review: The Role of Stem Cells in Cancer Progression and Therapy

The authors report on various studies in this field which focus on transformative properties of CSCs and their influence on surrounding cells or targets through the release of cellular cargo in the form of extracellular vesicles.
[Oncotargets and Therapy]
Hayat, H., Hayat, H., Dwan, B. F., Gudi, M., Bishop, J. O., & Wang, P. (2021). <p>A Concise Review: The Role of Stem Cells in Cancer Progression and Therapy</p>. OncoTargets and Therapy, 14, 2761–2772. https://doi.org/10.2147/OTT.S260391 Cite
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Nano-Realgar Suppresses Lung Cancer Stem Cell Growth by Repressing Metabolic Reprogramming

Isolation and characterization of lung cancer stem cells was performed by magnetic cell sorting and immunocytochemistry, respectively.
[Gene]
Yang, F., Zhao, Y., Hu, X., Liu, Z., Yu, X., Li, C., Li, X., & Li, H. (2021). Nano-realgar suppresses lung cancer stem cell growth by repressing metabolic reprogramming. Gene, 788, 145666. https://doi.org/10.1016/j.gene.2021.145666 Cite
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Glutamine Deficiency Promotes Stemness and Chemoresistance in Tumor Cells through DRP1-Induced Mitochondrial Fragmentation

Researchers showed that glutamine is dispensable for the survival of ovarian and colon cancer cells while it is required for their proliferation.
[Cellular and Molecular Life Sciences]
Prasad, P., Ghosh, S., & Roy, S. S. (2021). Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-021-03818-6 Cite
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EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma

Scientists established two sorafenib-resistant, patient-derived tumor xenografts that mimicked development of acquired resistance to sorafenib in hepatocellular carcinoma patients.
[Cancer Research]
Leung, H.-W., Leung, C. O.-N., Lau, E. Y., Chung, K. P. S., Mok, E. H., Lei, M. M. L., Leung, R. W. H., Tong, M., Keng, V. W., Ma, C., Zhao, Q., Ng, I. O.-L., Ma, S., & Lee, T. K. (2021). EPHB2 activates β-catenin to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-21-0184 Cite
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Microvesicles – Promising Tiny Players’ of Cancer Stem Cells Targeted Liver Cancer Treatments: The Interesting Interactions and Therapeutic Aspects

The authors summarize the existing evidence that supports the concept of microvesicles, the tiny particles have a big role behind the rare immortal cancer stem cells which controls the tumor initiation, propagation and metastasis in liver cancer.
[Pharmacological Research]
He, C., Ali, D. J., Aseervatham G, S. B., Sun, B., & Xiao, Z. (2021). Microvesicles – promising tiny players’ of cancer stem cells targeted liver cancer treatments: the interesting interactions and therapeutic aspects. Pharmacological Research, 105609. https://doi.org/10.1016/j.phrs.2021.105609 Cite
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Novel Role of LINC01013/miR-6795-5p/FMNL3 Axis in the Regulation of Hepatocellular Carcinoma Stem Cell Features

Hepatocellular carcinoma tissues and normal controls were collected, and the expression pattern of LINC01013 and miR-6795-5p was identified by quick real-time polymerase chain reaction.
[Acta Biochimica et Biophysica Sinica]
Wang, W., Xu, S., Di, Y., Zhang, Z., Li, Q., Guo, K., Lv, Y., & Wang, B. (2021). Novel role of LINC01013/miR-6795-5p/FMNL3 axis in the regulation of hepatocellular carcinoma stem cell features. Acta Biochimica et Biophysica Sinica, gmab040. https://doi.org/10.1093/abbs/gmab040 Cite
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Signaling Pathways Governing Breast Cancer Stem Cells Behavior

Scientists discuss known signaling mechanisms involved in the stimulation or prevention of breast cancer stem cells self-renewal, metastasis, and tumorigenesis.
[Stem Cell Research & Therapy]
Song, K., & Farzaneh, M. (2021). Signaling pathways governing breast cancer stem cells behavior. Stem Cell Research & Therapy, 12(1), 245. https://doi.org/10.1186/s13287-021-02321-w Cite
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BMP9-ID1 Signaling Promotes EpCAM-Positive Cancer Stem Cell Properties in Hepatocellular Carcinoma

Scientists aimed to elucidate the role of Bone morphologic protein 9 (BMP9) signaling in hepatocellular carcinoma-cancer stem cells (HCC‐CSC) properties and to assess the therapeutic effect of BMP receptor inhibitors in HCC.
[Molecular Oncology]
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A Cyclometalated IrIII Complex Conjugated to a Coumarin Derivative Is a Potent Photodynamic Agent against Prostate Differentiated and Tumorigenic Cancer Stem Cells

The authors showed. using DU145 tumor cells, taken as the model of hormone‐refractory and aggressive prostate cancer cells resistant to conventional antineoplastic drugs, that the photoactivated 3 very efficiently eliminated both prostate bulk, differentiated and prostate, hardly treatable cancer stem cells simultaneously and with a similar efficiency.
[Chemistry-A European Journal]
Novohradsky, V., Markova, L., Kostrhunova, H., Kasparkova, J., Ruiz, J., Marchán, V., & Brabec, V. (n.d.). A Cyclometalated IrIII Complex Conjugated to a Coumarin Derivative Is a Potent Photodynamic Agent against Prostate Differentiated and Tumorigenic Cancer Stem Cells. Chemistry – A European Journal, n/a(n/a). https://doi.org/https://doi.org/10.1002/chem.202100568 Cite
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The Cancer Stem Cell Niche in Ovarian Cancer and Its Impact on Immune Surveillance

Investigators summarize current evidence-based knowledge on the cancer stem cell niche within the ovarian cancer tumour microenvironment and its effect on immune surveillance.
[International Journal of Molecular Sciences]
Jain, S., Annett, S. L., Morgan, M. P., & Robson, T. (2021). The Cancer Stem Cell Niche in Ovarian Cancer and Its Impact on Immune Surveillance. International Journal of Molecular Sciences, 22(8), 4091. https://doi.org/10.3390/ijms22084091 Cite
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Cancer Stem Cell-Targeted Therapeutic Approaches for Overcoming Trastuzumab Resistance in HER2‐Positive Breast Cancer

The authors discuss the role of epithelial‐mesenchymal transition of breast cancer stem cells (BCSCs) in the setting of trastuzumab resistance and approaches of reducing or eradicating BCSCs in HER2positive breast cancer.
[Stem Cells]
Qiu, Y., Yang, L., Liu, H., & Luo, X. (n.d.). Cancer Stem Cell-Targeted Therapeutic Approaches for Overcoming Trastuzumab Resistance in HER2-Positive Breast Cancer. STEM CELLS, n/a(n/a). https://doi.org/https://doi.org/10.1002/stem.3381 Cite
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