Mesenchymal Stem Cell Therapy in Decompensated Liver Cirrhosis: A Long-Term Follow-Up Analysis of the Randomized Controlled Clinical Trial

Therapy of umbilical cord-derived MSC was not only well tolerated, but also significantly improved long-term survival rate, as well as the liver function in patients with Hepatits B Virus-related decompensated liver cirrhosis.
[Hepatology International]
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Three Researchers Honoured for Groundbreaking Work on Ovarian Cancer, Stem Cells and Blood Transfusions

Each year, the Ottawa Hospital honours three outstanding researchers for discoveries that are having an impact around the world. This year’s honourees have led game-changing discoveries and clinical trials in areas such as ovarian cancer, stem cells and blood transfusions.
[Ottawa Citizen]
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NR2F2 Controls Malignant Squamous Cell Carcinoma State by Promoting Stemness and Invasion and Repressing Differentiation

Using transcriptional profiling of cancer stem cells from benign tumors and malignant skin squamous cell carcinoma (SCC), scientists identified the nuclear receptor NR2F2 as uniquely expressed in malignant SCC.
[Nature Cancer]
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Heterogeneity of BCSCs Contributes to the Metastatic Organotropism of Breast Cancer

Scientists summarize current clinical trials, which assessed the safety and efficacy of breast cancer stem cells-related therapies.
[Journal of Experimental & Clinical Cancer Research]
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The Sulfiredoxin-Peroxiredoxin Redox System Regulates the Stemness and Survival of Colon Cancer Stem Cells

Scientists assessed the role of the sulfiredoxin-peroxiredoxin redox system and mitochondrial oxidative phosphorylation in maintaining the stemness and survival of colon CSCs.
[Redox Biology]
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ZRANB1 Enhances Stem-Cell-Like Features and Accelerates Tumor Progression by Regulating Sox9-Mediated USP22/Wnt/β-Catenin Pathway in Colorectal Cancer

Scientists examined the regulatory effects of ZRANB1 on the maintenance of CSC properties and tumor growth in colorectal cancer.
[Cellular Signalling]
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Autophagy Regulates the Cancer Stem Cell Phenotype of Head and Neck Squamous Cell Carcinoma through the Noncanonical FOXO3/SOX2 Axis

The mechanism by which autophagy affects the self-renewal of CSCs remains unclear. Researchers investigated whether autophagy activation contributes to CSC properties of head and neck squamous cell carcinoma.
[Oncogene]
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The Inhibition of Circular RNA circNOLC1 by Propofol/STAT3 Attenuates Breast Cancer Stem Cells Function via miR-365a-3p/STAT3 Signaling

Scientists explored the function of circular RNA nucleolar and coiled-body phosphoprotein 1 (circNOLC1) in cancer stem cells of breast cancer and the inhibitory impact of propofol on circNOLC1.
[Journal of Translational Medicine]
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The IVF-Generated Human Embryonic Microenvironment Reverses Progestin Resistance in Endometrial Cancer Cells by Inducing Cancer Stem Cell Differentiation

Scientists found that progestin resistance of endometrial CSCs could be improved or reversed by using in vitro fertilization (IVF)-generated embryonic sac-derived fluid containing the embryonic microenvironment.
[Cancer Letters]
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Circular RNA circPIP5K1A Contributes to Cancer Stemness of Osteosarcoma by miR-515-5p/YAP Axis

Circular RNA (circRNA) is a unique sort of non-coding RNAs and widely participate in the modulation of cancer progression. Researchers identified the critical function of circular RNA circPIP5K1A in stemness of osteosarcoma cells.
[Journal of Translational Medicine]
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Methionine Affects the Expression of Pluripotency Genes and Protein Levels Associated with Methionine Metabolism in Adult, Fetal, and Cancer Stem Cells

Scientists revealed the differences in methionine metabolism of bone marrow (BM)-mesenchymal stem cells (MSCs), umbilical cord blood-MSCs, and cancer stem cells, which reflect different metabolic profiles and developmental stages of stem cells.
[Journal of Cellular Biochemistry]
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