endothelial cells

[Cardiovascular Drugs and Therapy] Oxidized low-density lipoprotein was used to treat human umbilical vein endothelial cells to construct a cell injury model. The expression level of circCHMP5, miR-532-5p, and Rho-associated protein kinase 2 was measured using quantitative real-time PCR.

[Cellular and Molecular Life Sciences] The authors examine endothelial cell bone morphogenetic protein (BMP) signaling in vitro and in vivo and discuss the paradox of BMP signals that both destabilize and stabilize endothelial cell behaviors.

[Journal of Pathology] Scientists investigated the effect of reduced complement factor H (FH) levels in the choroid to determine whether increasing local FH could protect choroidal endothelial cells from membrane attack complex deposition.

[Scientific Reports] Researchers used global gene expression in human coronary artery endothelial cells to identify gene pathways and cellular processes in response to chemical hypoxia, oxidized lipids, IL-1β induced inflammation, oscillatory flow, and these combined stimuli.

[Nature Communications] Scientists showed that matrix degradation and chondrocyte phagocytosis were mediated by fatty acid binding protein 5-expressing cells representing septoclasts, which had a mesenchymal origin and were not derived from hematopoietic cells.

[Science] Investigators profiled transcriptomes of 181,388 cells to define a cell atlas of the adult human cerebrovasculature, including endothelial cell molecular signatures with arteriovenous segmentation and expanded perivascular cell diversity.