glioblastoma stem cells

[Molecular Cell] The authors report that protein arginine methyltransferase (PRMT) 6 activity is required for the proliferation, stem-like properties, and tumorigenicity of glioblastoma stem cells, a subpopulation in glioblastoma critical for malignancy.

[eLife] Researchers showed, using single-cell chromatin accessibility, that primary human glioblastomas (GBMs) harbored a heterogeneous self-renewing population whose diversity was captured in patient-derived GBMs stem cells.

[Cancer Gene Therapy] The Sleeping-Beauty transposon-induced glioblastoma model was used in leucine-rich repeat-containing G-protein coupled receptor 5-GFP knock-in mice identify GFP-positive cells in neurosphere cultures from mouse glioblastoma tissues

[Nature Cancer] The authors performed single-cell RNA sequencing on >69,000 glioblastoma stem cells (GSCs) cultured from the tumors of 26 patients. They observed a high degree of inter- and intra-GSC transcriptional heterogeneity that could not be fully explained by DNA somatic alterations.

[Oncogene] Deregulation of PARK7 has been implicated in the pathogenesis of various human diseases, including cancer. Scientists clarified the effect of PARK7 on stemness and radioresistance of glioblastoma stem cells.

[Cancer Discovery] Researchers interrogated N6-methyladenosine (m6A) mRNA modifications in glioma stem cells by methyl RNA-immunoprecipitation followed by sequencing and transcriptome analysis, finding transcripts marked by m6A often upregulated compared to normal neural stem cells.