hepatic cells

[Scientific Reports] Investigators reported a new approach that enables the formation of self-assembled 3D spheroids of adipose-derived stem cells and murine hepatocytes via reconstituted collagen fibers.

[Science Advances] Scientists demonstrated that 3D cultured organoids from fetal and adult human liver with cholangiocyte or hepatocyte phenotype supported hepatitis E virus replication.

[Scientific Reports] The authors determined if patatin-like phospholipase domain-containing protein 3 (PNPLA3), as well as other lipases, transcription factors, or fatty acid (FA)-mediated genes, were regulated by FA mimicking liver lipid accumulation and liver lipid clearing (RECOV) or singular FA physiologically found in dairy cows at 0.5 mM of circulating RECOV.

[Nature Communications] Using hepatocyte-, hepatoblast- and ductal cell-derived organoids, investigators demonstrated that the differentiation defects and lipid alterations were, in part, cell-autonomous.

[Science Signaling] Researchers reported the identification of a previously uncharacterized oncogenic signaling pathway in hepatocellular carcinoma that was mediated by the tyrosine kinase Yes.

[Advanced Materials] The authors systemically review the diverse interactions of nanomaterials with the liver, specifically on major liver cell types including Kupffer cells, liver sinusoidal endothelial cells, hepatic stellate cells, and hepatocytes as well as the detailed molecular mechanisms involved.