A 3D Primary Human Cell-Based In Vitro Model of Non-Alcoholic Steatohepatitis for Efficacy Testing of Clinical Drug Candidates

Investigators presented a 3D in vitro microtissue model that used spheroidal, scaffold free co-culture of primary human hepatocytes, Kupffer cells, liver endothelial cells and hepatic stellate cells.
[Scientific Reports]
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A New Perspective on NAFLD: Focusing on Lipid Droplets

Investigators provide a description of several key mechanisms that contribute to lipid droplet accumulation in the hepatocytes, favouring non-alcoholic fatty liver disease (NAFLD) progression.
[Journal of Hepatology]
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Liver Sphingomyelin Synthase 1 Deficiency Causes Steatosis, Steatohepatitis, Fibrosis and Tumorigenesis: An Effect of Glucosylceramide Accumulation

Investigators implicated that glucosylceramide accumulation was one of triggers promoting the development of nonalcoholic fatty liver disease into non-alcoholic steatohepatitis, then, fibrosis and tumorigenesis.
[iScience]
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Survivin Expression Is Essential for Early Activation of Hepatic Stellate Cells and Fibrosis Progression in Chronic Liver Injury

Researchers investigated the role of survivin protein in early fibrogenic activation of hepatic stellate cells and fibrosis progression in chronic liver injury.
[Life Sciences]
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MiR-571 Affects the Development and Progression of Liver Fibrosis by Regulating the Notch3 Pathway

Investigators found that miR-571 inhibited the apoptosis of human hepatic stellate cells and promoted cell proliferation and migration. Its up regulation promoted the expression of Notch3 and Jagged1, and promoted the expression of related fibroblasts.
[Scientific Reports]
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The Effects Of Autophagy Inhibition By Chloroquine On Hepatic Stellate Cell Activation In CCl4-induced Acute Liver Injury Mouse Model

The autophagy attenuation exerted by chloroquine together with the reduction of the expression of the proliferation marker in hepatic stellate cells could lessen the acute liver damage, potentially opening the way to novel therapeutic approaches for hepatic fibrosis.
[Journal of Gastroenterology and Hepatology]
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Single-Cell RNA Transcriptome Landscape of Hepatocytes and Non-Parenchymal Cells in Healthy and NAFLD Mouse Liver

To obtain a cellular resolution of pathogenesis, 82,168 single-cell transcriptomes across different nonalcoholic fatty liver disease stages were profiled, identifying hepatocytes and 12 other non-parenchymal cell types.
[iScience]
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Effect of Hepatocyte Growth Factor-Transfected Human Umbilical Cord Mesenchymal Stem Cells on Hepatic Stellate Cells by Regulating Transforming Growth Factor-β1/Smads Signaling Pathway

Investigators explored the possible mechanism of hepatocyte growth factor-transfectedhuman umbilical cord mesenchymal stem cells in inhibiting the proliferation and activation of hepatic stellate cells-T6.
[Stem Cells and Development]
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Effect and Mechanism of Vitamin D Activation Disorder on Liver Fibrosis in Biliary Atresia

Researchers investigated the effect of differential expression of CYP2R1 in hepatocytes on the expression of genes related to liver fibrosis in primary hepatic stellate cells of biliary atresia and animal models of cholestasis.
[Scientific Reports]
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Single-Cell and Bulk Transcriptomics of the Liver Reveals Potential Targets of NASH with Fibrosis

Scientists profiled 17,810 non-parenchymal cells derived from six healthy human livers, which enabled the identification of potential intercellular signaling axes and master regulators responsible for the activation of hepatic stellate cells during fibrogenesis.
[Scientific Reports]
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O-GlcNAcylation Inhibits Hepatic Stellate Cell Activation

The authors aimed to evaluate the role of O-GlcNAc transferase (OGT) in hepatic stellate cells (HSCs) and its consequent role in liver fibrosis. RNA-seq showed that OGT knockdown in HSCs modulated key signaling pathways involved in HSC activation.
[Journal of Gastroenterology and Hepatology]
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