hepatocytes

[Nature Communications] Using hepatocyte-, hepatoblast- and ductal cell-derived organoids, investigators demonstrated that the differentiation defects and lipid alterations were, in part, cell-autonomous.

[Science Signaling] Researchers reported the identification of a previously uncharacterized oncogenic signaling pathway in hepatocellular carcinoma that was mediated by the tyrosine kinase Yes.

[Advanced Materials] The authors systemically review the diverse interactions of nanomaterials with the liver, specifically on major liver cell types including Kupffer cells, liver sinusoidal endothelial cells, hepatic stellate cells, and hepatocytes as well as the detailed molecular mechanisms involved.

[Oncogene] Investigators used proteomics and single cell RNA-sequencing analysis to examine the cancer-associated fibroblast landscape in hepatocellular carcinoma.

[Acta Pharmacologica Sinica] Scientists investigated whether sapidolide A exerted protective effects on macrophages, thus alleviating the secondary hepatocyte damage in an acetaminophen-induced liver injury.

[Acta Pharmacologica Sinica] Researchers investigated whether tetramethylpyrazine exerted liver-protective action through regulating extracellular vesicle-dependent intercellular communication between hepatocytes and hepatic stellate cells.